Younger age is associated with higher levels of self-reported affective and cognitive sequelae six months post-cardiac arrest

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BACKGROUND: Affective and cognitive sequelae are frequently reported in cardiac arrest survivors; however, little is known about the risk factors. We assessed the hypothesis that self-reported affective and cognitive sequelae six months after OHCA may be associated with demography, acute care and cerebral outcome.

METHODS: This is a sub-study of the multicentre "Target Temperature Management for 48 vs. 24hours and Neurologic Outcome after Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial" (the TTH48 trial) investigating the effect of prolonged TTM at 33±1°C. We invited patients with good outcome on the Cerebral Performances Categories (CPC score≤2)to answer questionnaires on anxiety, depression, emotional distress, perceived stress and cognitive failures six months post OHCA.

RESULTS: In total 79 of 107 eligible patients were included in the analysis. There were no significant differences in baseline characteristics between the included group and the group lost to follow-up. Younger age was a negative predictor across all self-reported outcomes, even when controlling for gender, ROSC time, treatment allocation, cognitive impairment and global outcome (CPC 1 or 2). Female gender was a predictor of anxiety, though this should be interpreted cautiously as only eight women participated. A CPC score of 2 score was a negative predictor of self-reported affective outcomes, albeit not for self-reported cognitive failures.

CONCLUSION: Younger age was associated with higher levels of self-reported affective and cognitive sequelae six months post OHCA. Female gender may be associated with self-reported anxiety. A higher CPC score may be a proxy for self-reported affective sequelae.

Original languageEnglish
Publication statusE-pub ahead of print - 19 Apr 2021

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Copyright © 2021. Published by Elsevier B.V.

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