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Xanthine Quartets on Au(111)

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DOI

  • Chong Chen, Harbin Institute of Technology
  • ,
  • Hongqian Sang, Jianghan University
  • ,
  • Pengcheng Ding, Harbin Institute of Technology
  • ,
  • Ye Sun, Harbin Institute of Technology
  • ,
  • Manuela Mura, University of Lincoln
  • ,
  • Ying Hu, Harbin Institute of Technology
  • ,
  • Lev N. Kantorovich, King’s College London
  • ,
  • Flemming Besenbacher
  • Miao Yu, Harbin Institute of Technology

The quartet of xanthine (X), a purine base ubiquitously distributed in most human body tissues and fluids, has been for the first time fabricated and visualized, as the first alternative purine quartet besides the known guanine (G)-quartet. The X-quartet network is demonstrated to be the most stable phase on Au(111). Unlike guanine, the fabrication of the X-quartets is not dependent on the presence of metal atoms, which makes it the first metal-free purine quartet. Th, X-quartet holds great promise to potentially construct artificial new DNA quadruplexes for genetic regulation and antitumor therapy. Moreover, both the X-quartet itself and the quartet networks favor homochirality, suggesting homo-chiral xanthine oligomers and the networks may have been formed as the precursors of the pristine oligonucleotides on primitive Earth.

Original languageEnglish
JournalJournal of the American Chemical Society
Volume140
Issue1
Pages (from-to)54-57
Number of pages4
ISSN0002-7863
DOIs
Publication statusPublished - 10 Jan 2018

    Research areas

  • TERT PROMOTER MUTATIONS, G-QUADRUPLEX STRUCTURES, DNA, GUANINE, STABILITY, RELEVANCE, MELANOMA, ORIGIN, LIFE

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