Worsening of Verbal Fluency After Deep Brain Stimulation in Parkinson's Disease: A Focused Review

Andreas Højlund, Mikkel V. Petersen, Kousik Sarathy Sridharan, Karen Østergaard

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Abstract

Worsening of verbal fluency after treatment with deep brain stimulation in Parkinson's disease patients is one of the most often reported cognitive adverse effect. The underlying mechanisms of this decline are not well understood. The present focused review assesses the evidence for the reliability of the often-reported decline of verbal fluency, as well as the evidence for the suggested mechanisms including disease progression, reduced medication levels, electrode positions, and stimulation effect vs. surgical effects. Finally, we highlight the need for more systematic investigations of the large degree of heterogeneity in the prevalence of verbal fluency worsening after DBS, as well as provide suggestions for future research.

Original languageEnglish
JournalComputational and Structural Biotechnology Journal
Volume15
Pages (from-to)68-74
Number of pages7
ISSN2001-0370
Publication statusPublished - 27 Nov 2016

Keywords

  • Deep brain stimulation
  • Parkinson's disease
  • Verbal fluency

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