World Workshop on Oral Medicine VII: Biomarkers predicting lymphoma in the salivary glands of patients with Sjögren’s syndrome—A systematic review

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review


  • Konstantina Delli, Universitair Medisch Centrum Groningen
  • ,
  • Alessandro Villa, Brigham and Women's Hospital, Boston, Catalyst Laboratory for Innovative Translational Technologies, Harvard School of Dental Medicine
  • ,
  • Camile S. Farah, University of Western Australia
  • ,
  • Antonio Celentano, University of Melbourne
  • ,
  • David Ojeda, School of Dentistry
  • ,
  • Douglas Peterson, UConn Health
  • ,
  • Siri B. Jensen
  • Ingrid Glurich, Marshfield Clinic Research Institute
  • ,
  • Arjan Vissink, Universitair Medisch Centrum Groningen

Objective: To conduct a systematic review of studies exploring potential biomarkers for development, course, and efficacy of treatment of lymphomas in salivary glands of patients with Sjögren's syndrome. Material and Methods: Eligible studies were identified through a comprehensive search of two databases, that is, PubMed and EMBASE. Quality of included articles was assessed with the “Quality In Prognosis Studies” (QUIPS) tool. The “CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies” (CHARMS) was used to facilitate data extraction. Results: Fifty-eight studies met the inclusion criteria. Only one study assessed the progression of lymphoma. Moderate risk of bias was detected in “outcome measurement,” “study participation,” and “study confounding” domains. Parotid gland enlargement, mixed monoclonal cryoglobulins, and low C4 levels represented strongest predictors of lymphoma development. The role of histological biomarkers, and specifically germinal centers, remains controversial. Clinical and methodological heterogeneity across studies precluded conduct of a meta-analysis. Conclusions: Specific biomarkers in combination with clinical manifestations represent potential candidates for advancing precision medicine approaches to lymphoma prediction in patients with Sjögren's syndrome. Current focus has increasingly been on genetic and epigenetic markers as candidate predictors. Predictive accuracy of key biomarker candidates remains to be tested in well-designed prospectively followed Sjögren's syndrome cohorts.

Original languageEnglish
JournalOral Diseases
Pages (from-to)49-63
Number of pages15
Publication statusPublished - 2019

    Research areas

  • biomarker, lymphoma, prediction, salivary glands, Sjögren’s syndrome

See relations at Aarhus University Citationformats

ID: 156099234