World Workshop on Oral Medicine VII: Targeting the microbiome for oral medicine specialists—Part 1. A methodological guide

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  • Elena M. Varoni, Universita degli Studi di Milano
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  • Roxanne Bavarian, Brigham and Women's Hospital, Boston, Catalyst Laboratory for Innovative Translational Technologies, Harvard School of Dental Medicine
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  • Jairo Robledo-Sierra, CES University
  • ,
  • Dalit Porat Ben-Amy, The Baruch Padeh Medical Center
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  • William G. Wade, King's College London
  • ,
  • Bruce Paster, The Forsyth Institute
  • ,
  • Ross Kerr, New York University
  • ,
  • Douglas E. Peterson, Southern Connecticut State University
  • ,
  • Ellen Frandsen Lau

Advances in high-throughput sequencing technologies have allowed for a rapid increase in knowledge about the human microbiome in both healthy and diseased states, which is expected to increase our understanding of multifactorial diseases. The World Workshop on Oral Medicine VII chose the microbiome as one of its topics of focus. Part 1 of this review provides updated knowledge in the field of microbiome research, describes the advantages and disadvantages of currently available sequencing technologies, and proposes a seven-step “recipe” for designing and performing studies that is supported by contemporary evidence. Part 2 of this review in a companion paper discusses the results of high-throughput sequencing studies published to date on the microbiota associated with oral mucosal diseases. The goal of this collective enterprise is to encourage more oral medicine specialists to become engaged in multidisciplinary collaborations to investigate the role of the microbiome in relation to oral diseases, which could potentially lead to enhanced diagnosis, risk assessment and treatment of these patients.

Original languageEnglish
JournalOral Diseases
Issuesuppl. 1
Pages (from-to)12-27
Number of pages16
Publication statusPublished - 2019

    Research areas

  • BACTERIAL, DNA, EXTRACTION, HEALTH, IDENTIFICATION, IMPACT, PRIMER, SEQUENCE, SPECTROMETRY, TOOLS, metagenome, microbiome, next generation sequencing, omics, oral medicine, oral microbiome

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ID: 173145572