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Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

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Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. / Daetwyler, Hans D ; Capitan, Aurélien ; Pausch, Hubert et al.

In: Nature Genetics, Vol. 46, No. 8, 13.07.2014, p. 858 - 865.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Daetwyler, HD, Capitan, A, Pausch, H, Stothard, P, van Binsbergen, R, Brøndum, RF, Liao, X, Djari, A, Rodriguez, SC, Grohs, C, Jung, S, Esquerré, D, Bouchez, O, Gollnick, NS, Rossignol, M-N, Klopp, C, Rocha, D, Fritz, S, Eggen, A, Bowman, PJ, Coote, D, Chamberlain, AJ, VanTassell, CP, Hulsegge, I, Goddard, ME, Guldbrandtsen, B, Lund, MS, Veerkamp, RF, Boichard, DA, Fries, R & Hayes, BJ 2014, 'Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle', Nature Genetics, vol. 46, no. 8, pp. 858 - 865.

APA

Daetwyler, H. D., Capitan, A., Pausch, H., Stothard, P., van Binsbergen, R., Brøndum, R. F., Liao, X., Djari, A., Rodriguez, S. C., Grohs, C., Jung, S., Esquerré, D., Bouchez, O., Gollnick, N. S., Rossignol, M-N., Klopp, C., Rocha, D., Fritz, S., Eggen, A., ... Hayes, B. J. (2014). Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. Nature Genetics, 46(8), 858 - 865.

CBE

Daetwyler HD, Capitan A, Pausch H, Stothard P, van Binsbergen R, Brøndum RF, Liao X, Djari A, Rodriguez SC, Grohs C, et al. 2014. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. Nature Genetics. 46(8):858 - 865.

MLA

Daetwyler, Hans D et al. "Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle". Nature Genetics. 2014, 46(8). 858 - 865.

Vancouver

Daetwyler HD, Capitan A, Pausch H, Stothard P, van Binsbergen R, Brøndum RF et al. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. Nature Genetics. 2014 Jul 13;46(8):858 - 865.

Author

Daetwyler, Hans D ; Capitan, Aurélien ; Pausch, Hubert et al. / Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. In: Nature Genetics. 2014 ; Vol. 46, No. 8. pp. 858 - 865.

Bibtex

@article{cbdb51eeae424412a273cfb278199dde,
title = "Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle",
abstract = "The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle",
author = "Daetwyler, {Hans D} and Aur{\'e}lien Capitan and Hubert Pausch and Paul Stothard and {van Binsbergen}, Rianne and Br{\o}ndum, {Rasmus Froberg} and Xiaoping Liao and Anis Djari and Rodriguez, {Sabrina C} and C{\'e}cile Grohs and Simone Jung and Diane Esquerr{\'e} and Olivier Bouchez and Gollnick, {Nicole S} and Marie-No{\"e}lle Rossignol and Christophe Klopp and Dominique Rocha and S{\'e}bastien Fritz and Andr{\'e} Eggen and Bowman, {Phil J} and David Coote and Chamberlain, {Amanda J} and VanTassell, {Curt P} and Ina Hulsegge and Goddard, {Mike E} and Bernt Guldbrandtsen and Lund, {Mogens Sand{\o}} and Veerkamp, {Roel F} and Boichard, {Didier A} and Ruedi Fries and Hayes, {Ben J}",
note = "Project 12225",
year = "2014",
month = jul,
day = "13",
language = "English",
volume = "46",
pages = "858 -- 865",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

AU - Daetwyler, Hans D

AU - Capitan, Aurélien

AU - Pausch, Hubert

AU - Stothard, Paul

AU - van Binsbergen, Rianne

AU - Brøndum, Rasmus Froberg

AU - Liao, Xiaoping

AU - Djari, Anis

AU - Rodriguez, Sabrina C

AU - Grohs, Cécile

AU - Jung, Simone

AU - Esquerré, Diane

AU - Bouchez, Olivier

AU - Gollnick, Nicole S

AU - Rossignol, Marie-Noëlle

AU - Klopp, Christophe

AU - Rocha, Dominique

AU - Fritz, Sébastien

AU - Eggen, André

AU - Bowman, Phil J

AU - Coote, David

AU - Chamberlain, Amanda J

AU - VanTassell, Curt P

AU - Hulsegge, Ina

AU - Goddard, Mike E

AU - Guldbrandtsen, Bernt

AU - Lund, Mogens Sandø

AU - Veerkamp, Roel F

AU - Boichard, Didier A

AU - Fries, Ruedi

AU - Hayes, Ben J

N1 - Project 12225

PY - 2014/7/13

Y1 - 2014/7/13

N2 - The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle

AB - The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle

M3 - Journal article

VL - 46

SP - 858

EP - 865

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 8

ER -