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Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

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  • Hans D Daetwyler, Biosciences Research Division, Department of Primary Industries, Bundoora, Australia
  • Aurélien Capitan, INRA, UMR1313 Génétique Animale et Biologie Intégrative, France
  • Hubert Pausch, Chair of Animal Breeding, Technische Universitaet Muenchen, Germany
  • Paul Stothard, Department of Agricultural, Food and Nutritional Science, University of Alberta, Canada
  • Rianne van Binsbergen, Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, Netherlands
  • Rasmus Froberg Brøndum, Denmark
  • Xiaoping Liao, Department of Agricultural, Food and Nutritional Science, University of Al, Canada
  • Anis Djari, INRA, Sigenae Bioinformatics Group, France
  • Sabrina C Rodriguez, INRA, UMR1313 Génétique Animale et Biologie Intégrative, France
  • Cécile Grohs, INRA, UMR1313 Génétique Animale et Biologie Intégrative, France
  • Simone Jung, Chair of Animal Breeding, Technische Universitaet Muenchen, Germany
  • Diane Esquerré, INRA, Get-Plage, UMR444 Laboratoire de Génétique Cellulaire, France
  • Olivier Bouchez, INRA, Get-Plage, UMR444 Laboratoire de Génétique Cellulaire, France
  • Nicole S Gollnick, Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for 32 Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet Muenchen, Germany
  • Marie-Noëlle Rossignol, LABOGENA, France
  • Christophe Klopp, INRA, Sigenae Bioinformatics Group, France
  • Dominique Rocha, INRA, UMR1313 Génétique Animale et Biologie Intégrative, France
  • Sébastien Fritz, Union Nationale des Coopératives d’Elevage et d’Insémination Animale, France
  • André Eggen, INRA, UMR1313 Génétique Animale et Biologie Intégrative, France
  • Phil J Bowman, Biosciences Research Division, Department of Primary Industries, Bundoora, Australia
  • David Coote, Biosciences Research Division, Department of Primary Industries, Bundoora, Australia
  • Amanda J Chamberlain, Biosciences Research Division, Department of Primary Industries, Bundoora, Australia
  • Curt P VanTassell, USDA-ARS, ANRI, Bovine Functional Genomics Laboratory, United States
  • Ina Hulsegge, Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, Netherlands
  • Mike E Goddard, Biosciences Research Division, Department of Primary Industries, Bundoora, Australia
  • Bernt Guldbrandtsen, Denmark
  • Mogens Sandø Lund
  • Roel F Veerkamp, Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, Netherlands
  • Didier A Boichard, INRA, UMR1313 Génétique Animale et Biologie Intégrative, France
  • Ruedi Fries, Chair of Animal Breeding, Technische Universitaet Muenchen, Germany
  • Ben J Hayes, Biosciences Research Division, Department of Primary Industries, Bundoora, Australia
The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle
Original languageEnglish
JournalNature Genetics
Volume46
Issue8
Pages (from-to)858 - 865
Number of pages7
ISSN1061-4036
Publication statusPublished - 13 Jul 2014

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Project 12225

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