Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia.

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  • A Gjedde, Denmark
  • J J Caronna, Denmark
  • B Hindfelt, Denmark
  • F Plum, Denmark
  • Positron Emission Tomography Center
The Kety-Schmidt washout technique has been modified to measure whole-brain blood flow and metabolism in the rat. During nitrous oxide anesthesia, 14 rats exhaled (133)Xe, and continuous and simultaneous arterial and cerebral venous samples were drawn from a femoral artery and the transverse sinus of the brain. Extracerebral contamination of the venous sample was minimal, and equilibration of (133)Xe in brain tissue and blood was obtained after 10-24 min of inhalation. Cerebral blood flow was calculated from the total activity of the mechanically integrated arterial and venous samples according to the principle of Scheinberg and Stead. At a mean Paco2 of 40 mmHg, CBF averaged 98 +/- 6 (SEM) ml/100 g-min and CMRO2 averaged 5.4 +/- 0.7 (SEM) ml/100 g-min. CBF changed 2.4% with each millimeter Hg change of Paco2 while CMRO2 changed only insignificantly. The values obtained for CBF are higher than reported for man and large laboratory animals bur reflect the proportionately greater amount of gray matter in the rat brain.
Original languageEnglish
JournalAmerican Journal of Physiology (Consolidated)
Pages (from-to)113-8
Number of pages5
Publication statusPublished - 1975

    Research areas

  • Anesthesia, Inhalation, Animals, Blood Flow Velocity, Blood Gas Analysis, Brain, Brain Chemistry, Carbon Dioxide, Cerebrovascular Circulation, Hypercapnia, Male, Nitrous Oxide, Oxygen, Oxygen Consumption, Rats, Veins, Xenon Radioisotopes

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