Whole-grain intake in mid-life and healthy ageing in the Danish Diet, Cancer and Health cohort

TY - JOUR

T1 - Whole-grain intake in mid-life and healthy ageing in the Danish Diet, Cancer and Health cohort

AU - Eriksen, Anne Kirstine

AU - Grand, Mia Klinten

AU - Kyrø, Cecilie

AU - Wohlfahrt, Jan

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Olsen, Anja

N1 - © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.

PY - 2024/8

Y1 - 2024/8

N2 - PURPOSE: Growing elderly populations worldwide have sparked interest in factors promoting healthy aging. Diet and other lifestyle patterns are key factors for healthy ageing; however, evidence is sparse for specific dietary guidelines that are easily implemented in everyday life. Whole grains constitute specific dietary components with unexplored potential in healthy ageing.METHODS: We applied an illness-death multistate model to assess the association between whole-grain intake and life expectancy, both with and without disease, over a 20-year period. Healthy ageing was defined as absence of cancer, ischemic heart disease, stroke, type 2 diabetes, asthma, chronic obstructive pulmonary disease, and dementia during follow-up.RESULTS: Based on information from 22,606 men and 25,468 women in the Danish Diet, Cancer and Health cohort, followed for an average of 13.8 and 17.5 years, respectively, a doubling in whole-grain intake was associated with 0.43 (95% CI: 0.33-0.52) and 0.15 (0.06-0.24) additional years without disease for men and women, respectively. Comparing the highest and lowest quartiles of whole-grain intake, with a special emphasis on men, we found that those with the highest intake lived, on average, one year longer without disease compared to those with the lowest intake. Additionally, although a high intake of whole grains yielded longer life expectancy, the duration of living with disease was shorter.CONCLUSION: Intake of whole grains in mid-life was associated with healthy ageing looking 20 years ahead.

AB - PURPOSE: Growing elderly populations worldwide have sparked interest in factors promoting healthy aging. Diet and other lifestyle patterns are key factors for healthy ageing; however, evidence is sparse for specific dietary guidelines that are easily implemented in everyday life. Whole grains constitute specific dietary components with unexplored potential in healthy ageing.METHODS: We applied an illness-death multistate model to assess the association between whole-grain intake and life expectancy, both with and without disease, over a 20-year period. Healthy ageing was defined as absence of cancer, ischemic heart disease, stroke, type 2 diabetes, asthma, chronic obstructive pulmonary disease, and dementia during follow-up.RESULTS: Based on information from 22,606 men and 25,468 women in the Danish Diet, Cancer and Health cohort, followed for an average of 13.8 and 17.5 years, respectively, a doubling in whole-grain intake was associated with 0.43 (95% CI: 0.33-0.52) and 0.15 (0.06-0.24) additional years without disease for men and women, respectively. Comparing the highest and lowest quartiles of whole-grain intake, with a special emphasis on men, we found that those with the highest intake lived, on average, one year longer without disease compared to those with the lowest intake. Additionally, although a high intake of whole grains yielded longer life expectancy, the duration of living with disease was shorter.CONCLUSION: Intake of whole grains in mid-life was associated with healthy ageing looking 20 years ahead.

KW - Epidemiology

KW - Healthy ageing

KW - Prevention

KW - Whole grains

UR - http://www.scopus.com/inward/record.url?scp=85186876777&partnerID=8YFLogxK

U2 - 10.1007/s00394-024-03357-3

DO - 10.1007/s00394-024-03357-3

M3 - Journal article

C2 - 38451283

SN - 1436-6207

VL - 63

SP - 1581

EP - 1591

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 5

ER -