Who prescribes quetiapine in Denmark?

Mikkel Højlund*, Lotte Rasmussen, Morten Olesen, Trine Munk-Olsen, Anton Pottegård

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Abstract

The second-generation antipsychotic quetiapine is commonly used off-label for its anxiolytic and hypnotic properties. However, quetiapine is associated with problematic side-effects. We used Danish Medicinal Product Statistics and a 20% random sample of the Danish population's prescription fills (2001–2020) to describe the utilization of quetiapine and proportion of various prescriber types (general practitioner [GP], specialist in private practice, hospital physician and other prescribers) both in connection to first-time and subsequent prescriptions. In 2020, 92% of all quetiapine was dispensed outside hospitals and the average daily dispensed quantity of quetiapine per user corresponded to 100 mg/user/d. A GP issued 53% of first-time prescriptions and 75% of subsequent prescriptions for quetiapine in 2020. The proportion of quetiapine prescriptions issued by GPs varied by age group—from 14% among 0–17-year-olds to 93% among the ≥80-year-olds. Future initiatives on the rational use of quetiapine and related drugs, especially among adults, should target GPs.

Original languageEnglish
JournalBritish Journal of Clinical Pharmacology
Volume88
Issue9
Pages (from-to)4224-4229
Number of pages6
ISSN0264-3774
DOIs
Publication statusPublished - Sept 2022

Keywords

  • antipsychotics
  • off-label
  • prescriber
  • quetiapine
  • PHARMACOLOGY
  • DRUGS
  • General Practitioners
  • Humans
  • Antipsychotic Agents/adverse effects
  • Practice Patterns, Physicians'
  • Quetiapine Fumarate/adverse effects
  • Denmark
  • Adult

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