TY - JOUR
T1 - White matter biomarkers from diffusion MRI
AU - Jespersen, Sune
PY - 2018/6
Y1 - 2018/6
N2 - Abstract As part of an issue celebrating 2 decades of Joseph Ackerman editing the Journal of Magnetic Resonance, this paper reviews recent progress in one of the many areas in which Ackerman and his lab has made significant contributions: NMR measurement of diffusion in biological media, specifically in brain tissue. NMR diffusion signals display exquisite sensitivity to tissue microstructure, and have the potential to offer quantitative and specific information on the cellular scale orders of magnitude below nominal image resolution when combined with biophysical modeling. Here, I offer a personal perspective on some recent advances in diffusion imaging, from diffusion kurtosis imaging to microstructural modeling, and the connection between the two. A new result on the estimation accuracy of axial and radial kurtosis with axially symmetric DKI is presented. I moreover touch upon recently suggested generalized diffusion sequences, promising to offer independent microstructural information. We discuss the need and some methods for validation, and end with an outlook on some promising future directions.
AB - Abstract As part of an issue celebrating 2 decades of Joseph Ackerman editing the Journal of Magnetic Resonance, this paper reviews recent progress in one of the many areas in which Ackerman and his lab has made significant contributions: NMR measurement of diffusion in biological media, specifically in brain tissue. NMR diffusion signals display exquisite sensitivity to tissue microstructure, and have the potential to offer quantitative and specific information on the cellular scale orders of magnitude below nominal image resolution when combined with biophysical modeling. Here, I offer a personal perspective on some recent advances in diffusion imaging, from diffusion kurtosis imaging to microstructural modeling, and the connection between the two. A new result on the estimation accuracy of axial and radial kurtosis with axially symmetric DKI is presented. I moreover touch upon recently suggested generalized diffusion sequences, promising to offer independent microstructural information. We discuss the need and some methods for validation, and end with an outlook on some promising future directions.
KW - Diffusion
KW - Double diffusion encoding
KW - Isotropic diffusion encoding
KW - Kurtosis
KW - Microstructure
KW - Modeling
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=85046706830&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2018.03.001
DO - 10.1016/j.jmr.2018.03.001
M3 - Tidsskriftartikel
C2 - 29705041
SN - 1090-7807
VL - 291
SP - 127
EP - 140
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
ER -