Wheat ferritins: Improving the iron content of the wheat grain

Søren Borg; Henrik Brinch-Pedersen; Birgitte Tauris; Lene Heegaard Madsen; Behrooz Darbani Shirvanehdeh; Shahin Noeparvar; Preben Bach Holm

doi:10.1016/j.jcs.2012.03.005

Wheat ferritins: Improving the iron content of the wheat grain

Søren Borg, Henrik Brinch-Pedersen, Birgitte Tauris, Lene Heegaard Madsen, Behrooz Darbani Shirvanehdeh, Shahin Noeparvar, Preben Bach Holm

Department of Agroecology - Crop Genetics and Biotechnology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

126 Citations (Scopus)

Abstract

The characterization of the full complement of wheat ferritins show that the modern hexaploid wheat genome contains two ferritin genes, TaFer1 and TaFer2, each represented by three homeoalleles and placed on chromosome 5 and 4, respectively. The two genes are differentially regulated and expressed. The TaFer1 genes are, except in the endosperm, the most abundantly expressed and regulated by iron and abscisic acid status. The promoter of TaFer1, in contrast to TaFer2, has iron- and ABA-responsive elements, supporting the expression data. The TaFer1 and TaFer2 genes encode two isoforms, probably functional different and acting in heteropolymer structures of ferritin in cereals. Iron biofortification of the wheat grain is possible. Endosperm targeted intragenic overexpressing of the TaFer1-A gene results in a 50-85 % higher iron content in the grain.

Original language	English
Journal	Journal of Cereal Science
Volume	56
Issue	2
Pages (from-to)	204-213
Number of pages	10
ISSN	0733-5210
DOIs	https://doi.org/10.1016/j.jcs.2012.03.005
Publication status	Published - Sept 2012

Keywords

Malnutrition
Iron
Ferritin
Biofortification

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10.1016/j.jcs.2012.03.005

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title = "Wheat ferritins: Improving the iron content of the wheat grain",

abstract = "The characterization of the full complement of wheat ferritins show that the modern hexaploid wheat genome contains two ferritin genes, TaFer1 and TaFer2, each represented by three homeoalleles and placed on chromosome 5 and 4, respectively. The two genes are differentially regulated and expressed. The TaFer1 genes are, except in the endosperm, the most abundantly expressed and regulated by iron and abscisic acid status. The promoter of TaFer1, in contrast to TaFer2, has iron- and ABA-responsive elements, supporting the expression data. The TaFer1 and TaFer2 genes encode two isoforms, probably functional different and acting in heteropolymer structures of ferritin in cereals. Iron biofortification of the wheat grain is possible. Endosperm targeted intragenic overexpressing of the TaFer1-A gene results in a 50-85 % higher iron content in the grain.",

keywords = "Malnutrition, Iron, Ferritin, Biofortification",

author = "S{\o}ren Borg and Henrik Brinch-Pedersen and Birgitte Tauris and Madsen, {Lene Heegaard} and Shirvanehdeh, {Behrooz Darbani} and Shahin Noeparvar and Holm, {Preben Bach}",

year = "2012",

month = sep,

doi = "10.1016/j.jcs.2012.03.005",

language = "English",

volume = "56",

pages = "204--213",

journal = "Journal of Cereal Science",

issn = "0733-5210",

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TY - JOUR

T1 - Wheat ferritins: Improving the iron content of the wheat grain

AU - Borg, Søren

AU - Brinch-Pedersen, Henrik

AU - Tauris, Birgitte

AU - Madsen, Lene Heegaard

AU - Shirvanehdeh, Behrooz Darbani

AU - Noeparvar, Shahin

AU - Holm, Preben Bach

PY - 2012/9

Y1 - 2012/9

N2 - The characterization of the full complement of wheat ferritins show that the modern hexaploid wheat genome contains two ferritin genes, TaFer1 and TaFer2, each represented by three homeoalleles and placed on chromosome 5 and 4, respectively. The two genes are differentially regulated and expressed. The TaFer1 genes are, except in the endosperm, the most abundantly expressed and regulated by iron and abscisic acid status. The promoter of TaFer1, in contrast to TaFer2, has iron- and ABA-responsive elements, supporting the expression data. The TaFer1 and TaFer2 genes encode two isoforms, probably functional different and acting in heteropolymer structures of ferritin in cereals. Iron biofortification of the wheat grain is possible. Endosperm targeted intragenic overexpressing of the TaFer1-A gene results in a 50-85 % higher iron content in the grain.

AB - The characterization of the full complement of wheat ferritins show that the modern hexaploid wheat genome contains two ferritin genes, TaFer1 and TaFer2, each represented by three homeoalleles and placed on chromosome 5 and 4, respectively. The two genes are differentially regulated and expressed. The TaFer1 genes are, except in the endosperm, the most abundantly expressed and regulated by iron and abscisic acid status. The promoter of TaFer1, in contrast to TaFer2, has iron- and ABA-responsive elements, supporting the expression data. The TaFer1 and TaFer2 genes encode two isoforms, probably functional different and acting in heteropolymer structures of ferritin in cereals. Iron biofortification of the wheat grain is possible. Endosperm targeted intragenic overexpressing of the TaFer1-A gene results in a 50-85 % higher iron content in the grain.

KW - Malnutrition

KW - Iron

KW - Ferritin

KW - Biofortification

U2 - 10.1016/j.jcs.2012.03.005

DO - 10.1016/j.jcs.2012.03.005

M3 - Journal article

SN - 0733-5210

VL - 56

SP - 204

EP - 213

JO - Journal of Cereal Science

JF - Journal of Cereal Science

IS - 2

ER -

Wheat ferritins: Improving the iron content of the wheat grain

Abstract

Keywords

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