Weighing the evidence for using vascular conductance, not resistance, in comparative cardiovascular physiology

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Weighing the evidence for using vascular conductance, not resistance, in comparative cardiovascular physiology. / Joyce, William; White, Daniel W.; Raven, Peter B.; Wang, Tobias.

In: The Journal of Experimental Biology, Vol. 222, No. March, 2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

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Joyce, William ; White, Daniel W. ; Raven, Peter B. ; Wang, Tobias. / Weighing the evidence for using vascular conductance, not resistance, in comparative cardiovascular physiology. In: The Journal of Experimental Biology. 2019 ; Vol. 222, No. March.

Bibtex

@article{f99709ee1b984db49c2a2b58cdd1dab5,
title = "Weighing the evidence for using vascular conductance, not resistance, in comparative cardiovascular physiology",
abstract = "Vascular resistance and conductance are reciprocal indices of vascular tone that are often assumed to be interchangeable. However, in most animals in vivo, blood flow (i.e. cardiac output) typically varies much more than arterial blood pressure. When blood flow changes at a constant pressure, the relationship between conductance and blood flow is linear, whereas the relationship between resistance and blood flow is non-linear. Thus, for a given change in blood flow, the change in resistance depends on the starting point, whereas the attendant change in conductance is proportional to the change in blood flow regardless of the starting conditions. By comparing the effects of physical activity at different temperatures or between species - concepts at the heart of comparative cardiovascular physiology - we demonstrate that the difference between choosing resistance or conductance can be marked. We also explain here how the ratio of conductance in the pulmonary and systemic circulations provides a more intuitive description of cardiac shunt patterns in the reptilian cardiovascular system than the more commonly used ratio of resistance. Finally, we posit that, although the decision to use conductance or resistance should be made on a case-by-case basis, in most circumstances, conductance is a more faithful portrayal of cardiovascular regulation in vertebrates.",
keywords = "Cardiac output, Cardiac shunting, Exercise, Vasodilation",
author = "William Joyce and White, {Daniel W.} and Raven, {Peter B.} and Tobias Wang",
year = "2019",
doi = "10.1242/jeb.197426",
language = "English",
volume = "222",
journal = "BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY",
issn = "0022-0949",
publisher = "The/Company of Biologists Ltd.",
number = "March",

}

RIS

TY - JOUR

T1 - Weighing the evidence for using vascular conductance, not resistance, in comparative cardiovascular physiology

AU - Joyce, William

AU - White, Daniel W.

AU - Raven, Peter B.

AU - Wang, Tobias

PY - 2019

Y1 - 2019

N2 - Vascular resistance and conductance are reciprocal indices of vascular tone that are often assumed to be interchangeable. However, in most animals in vivo, blood flow (i.e. cardiac output) typically varies much more than arterial blood pressure. When blood flow changes at a constant pressure, the relationship between conductance and blood flow is linear, whereas the relationship between resistance and blood flow is non-linear. Thus, for a given change in blood flow, the change in resistance depends on the starting point, whereas the attendant change in conductance is proportional to the change in blood flow regardless of the starting conditions. By comparing the effects of physical activity at different temperatures or between species - concepts at the heart of comparative cardiovascular physiology - we demonstrate that the difference between choosing resistance or conductance can be marked. We also explain here how the ratio of conductance in the pulmonary and systemic circulations provides a more intuitive description of cardiac shunt patterns in the reptilian cardiovascular system than the more commonly used ratio of resistance. Finally, we posit that, although the decision to use conductance or resistance should be made on a case-by-case basis, in most circumstances, conductance is a more faithful portrayal of cardiovascular regulation in vertebrates.

AB - Vascular resistance and conductance are reciprocal indices of vascular tone that are often assumed to be interchangeable. However, in most animals in vivo, blood flow (i.e. cardiac output) typically varies much more than arterial blood pressure. When blood flow changes at a constant pressure, the relationship between conductance and blood flow is linear, whereas the relationship between resistance and blood flow is non-linear. Thus, for a given change in blood flow, the change in resistance depends on the starting point, whereas the attendant change in conductance is proportional to the change in blood flow regardless of the starting conditions. By comparing the effects of physical activity at different temperatures or between species - concepts at the heart of comparative cardiovascular physiology - we demonstrate that the difference between choosing resistance or conductance can be marked. We also explain here how the ratio of conductance in the pulmonary and systemic circulations provides a more intuitive description of cardiac shunt patterns in the reptilian cardiovascular system than the more commonly used ratio of resistance. Finally, we posit that, although the decision to use conductance or resistance should be made on a case-by-case basis, in most circumstances, conductance is a more faithful portrayal of cardiovascular regulation in vertebrates.

KW - Cardiac output

KW - Cardiac shunting

KW - Exercise

KW - Vasodilation

UR - http://www.scopus.com/inward/record.url?scp=85063950851&partnerID=8YFLogxK

U2 - 10.1242/jeb.197426

DO - 10.1242/jeb.197426

M3 - Review

C2 - 30918087

AN - SCOPUS:85063950851

VL - 222

JO - BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY

JF - BRITISH JOURNAL OF EXPERIMENTAL BIOLOGY

SN - 0022-0949

IS - March

ER -