We Are Not Alone: The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • Andreas Tholey, Christian-Albrechts-Universität zu Kiel
  • ,
  • Nicolas L. Taylor, University of Western Australia
  • ,
  • Joshua L. Heazlewood, University Melbourne
  • ,
  • Emøke Bendixen

Mapping of the human proteome has advanced significantly in recent years and will provide a knowledge base to accelerate our understanding of how proteins and protein networks can affect human health and disease. However, providing solutions to human health challenges will likely fail if insights are exclusively based on studies of human samples and human proteomes. In recent years, it has become evident that human health depends on an integrated understanding of the many species that make human life possible. These include the commensal microorganisms that are essential to human life, pathogens, and food species as well as the classic model organisms that enable studies of biological mechanisms. The Human Proteome Organization (HUPO) initiative on multiorganism proteomes (iMOP) works to support proteome research undertaken on nonhuman species that remain widely under-studied compared with the progress in human proteome research. This perspective argues the need for further research on multiple species that impact human life. We also present an update on recent progress in model organisms, microbiota, and food species, address the emerging problem of antibiotics resistance, and outline how iMOP activities could lead to a more inclusive approach for the human proteome project (HPP) to better support proteome research aimed at improving human health and furthering knowledge on human biology.

Original languageEnglish
JournalJournal of Proteome Research
Volume16
Issue12
Pages (from-to)4273-4280
Number of pages8
ISSN1535-3893
DOIs
Publication statusPublished - 1 Dec 2017

    Research areas

  • crops, farm animals, food safety, iMOP, microbiome, model organisms, One Health, pathogens, veterinary health, zoonosis

See relations at Aarhus University Citationformats

ID: 120109335