TY - JOUR
T1 - Water channels in the brain and spinal cord
T2 - Overview of the role of aquaporins in traumatic brain injury and traumatic spinal cord injury
AU - Wichmann, Thea Overgaard
AU - Hedegaard Højsager, Marie
AU - Damkier, Helle Hasager
PY - 2024/5
Y1 - 2024/5
N2 - Knowledge about the mechanisms underlying the fluid flow in the brain and spinal cord is essential for discovering the mechanisms implicated in the pathophysiology of central nervous system diseases. During recent years, research has highlighted the complexity of the fluid flow movement in the brain through a glymphatic system and a lymphatic network. Less is known about these pathways in the spinal cord. An important aspect of fluid flow movement through the glymphatic pathway is the role of water channels, especially aquaporin 1 and 4. This review provides an overview of the role of these aquaporins in brain and spinal cord, and give a short introduction to the fluid flow in brain and spinal cord during in the healthy brain and spinal cord as well as during traumatic brain and spinal cord injury. Finally, this review gives an overview of the current knowledge about the role of aquaporins in traumatic brain and spinal cord injury, highlighting some of the complexities and knowledge gaps in the field.
AB - Knowledge about the mechanisms underlying the fluid flow in the brain and spinal cord is essential for discovering the mechanisms implicated in the pathophysiology of central nervous system diseases. During recent years, research has highlighted the complexity of the fluid flow movement in the brain through a glymphatic system and a lymphatic network. Less is known about these pathways in the spinal cord. An important aspect of fluid flow movement through the glymphatic pathway is the role of water channels, especially aquaporin 1 and 4. This review provides an overview of the role of these aquaporins in brain and spinal cord, and give a short introduction to the fluid flow in brain and spinal cord during in the healthy brain and spinal cord as well as during traumatic brain and spinal cord injury. Finally, this review gives an overview of the current knowledge about the role of aquaporins in traumatic brain and spinal cord injury, highlighting some of the complexities and knowledge gaps in the field.
KW - aquaporins
KW - glymphatic system
KW - lymphatic network
KW - traumatic brain injury
KW - traumatic spinal cord injury
UR - http://www.scopus.com/inward/record.url?scp=85194749909&partnerID=8YFLogxK
U2 - 10.3389/fncel.2024.1414662
DO - 10.3389/fncel.2024.1414662
M3 - Review
C2 - 38818518
SN - 1662-5102
VL - 18
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
M1 - 1414662
ER -