Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus. / Chen, Fenghua; du Jardin, Kristian Gaarn; Waller, Jessica A; Sanchez, Connie; Nyengaard, Jens R; Wegener, Gregers.

In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 26, No. 2, 02.2016, p. 234-245.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Chen, F, du Jardin, KG, Waller, JA, Sanchez, C, Nyengaard, JR & Wegener, G 2016, 'Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus', European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, vol. 26, no. 2, pp. 234-245. https://doi.org/10.1016/j.euroneuro.2015.12.018

APA

Chen, F., du Jardin, K. G., Waller, J. A., Sanchez, C., Nyengaard, J. R., & Wegener, G. (2016). Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 26(2), 234-245. https://doi.org/10.1016/j.euroneuro.2015.12.018

CBE

Chen F, du Jardin KG, Waller JA, Sanchez C, Nyengaard JR, Wegener G. 2016. Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(2):234-245. https://doi.org/10.1016/j.euroneuro.2015.12.018

MLA

Chen, Fenghua et al. "Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus". European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2016, 26(2). 234-245. https://doi.org/10.1016/j.euroneuro.2015.12.018

Vancouver

Chen F, du Jardin KG, Waller JA, Sanchez C, Nyengaard JR, Wegener G. Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2016 Feb;26(2):234-245. https://doi.org/10.1016/j.euroneuro.2015.12.018

Author

Chen, Fenghua ; du Jardin, Kristian Gaarn ; Waller, Jessica A ; Sanchez, Connie ; Nyengaard, Jens R ; Wegener, Gregers. / Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus. In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2016 ; Vol. 26, No. 2. pp. 234-245.

Bibtex

@article{b1c42a6ad03249dbad535ac33c741400,
title = "Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus",
abstract = "Preclinical studies reveal that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). In the present study, we investigated vortioxetine׳s effects on spines and dendritic morphology in rat hippocampus at two time points compared to the SSRI, fluoxetine. Rats were dosed for 1 and 4 weeks with vortioxetine and fluoxetine at doses relevant for antidepressant activity. Dendritic morphology of pyramidal neurons (i.e., dendritic length, dendritic branch, spine number and density, and Sholl analysis) was examined in Golgi-stained sections from hippocampal CA1. After 1 week of treatment, vortioxetine significantly increased spine number (apical and basal dendrites), spine density (only basal), dendritic length (only apical), and dendritic branch number (apical and basal), whereas fluoxetine had no effect. After 4 weeks of treatment, vortioxetine significantly increased all measures of dendritic spine morphology as did fluoxetine except for spine density of basal dendrites. The number of intersections in the apical and basal dendrites was also significantly increased for both treatments after 4 weeks compared to control. In addition, 4 weeks of vortioxetine treatment, but not fluoxetine, promoted a decrease in spine neck length. In conclusion, 1-week vortioxetine treatment induced changes in spine number and density and dendritic morphology, whereas an equivalent dose of fluoxetine had no effects. Decreased spine neck length following 4-week vortioxetine treatment suggests a transition to mature spine morphology. This implies that vortioxetine׳s effects on spine and dendritic morphology are mediated by mechanisms that go beyond serotonin reuptake inhibition.",
author = "Fenghua Chen and {du Jardin}, {Kristian Gaarn} and Waller, {Jessica A} and Connie Sanchez and Nyengaard, {Jens R} and Gregers Wegener",
note = "Copyright {\textcopyright} 2015 Elsevier B.V. and ECNP. All rights reserved.",
year = "2016",
month = feb,
doi = "10.1016/j.euroneuro.2015.12.018",
language = "English",
volume = "26",
pages = "234--245",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus

AU - Chen, Fenghua

AU - du Jardin, Kristian Gaarn

AU - Waller, Jessica A

AU - Sanchez, Connie

AU - Nyengaard, Jens R

AU - Wegener, Gregers

N1 - Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

PY - 2016/2

Y1 - 2016/2

N2 - Preclinical studies reveal that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). In the present study, we investigated vortioxetine׳s effects on spines and dendritic morphology in rat hippocampus at two time points compared to the SSRI, fluoxetine. Rats were dosed for 1 and 4 weeks with vortioxetine and fluoxetine at doses relevant for antidepressant activity. Dendritic morphology of pyramidal neurons (i.e., dendritic length, dendritic branch, spine number and density, and Sholl analysis) was examined in Golgi-stained sections from hippocampal CA1. After 1 week of treatment, vortioxetine significantly increased spine number (apical and basal dendrites), spine density (only basal), dendritic length (only apical), and dendritic branch number (apical and basal), whereas fluoxetine had no effect. After 4 weeks of treatment, vortioxetine significantly increased all measures of dendritic spine morphology as did fluoxetine except for spine density of basal dendrites. The number of intersections in the apical and basal dendrites was also significantly increased for both treatments after 4 weeks compared to control. In addition, 4 weeks of vortioxetine treatment, but not fluoxetine, promoted a decrease in spine neck length. In conclusion, 1-week vortioxetine treatment induced changes in spine number and density and dendritic morphology, whereas an equivalent dose of fluoxetine had no effects. Decreased spine neck length following 4-week vortioxetine treatment suggests a transition to mature spine morphology. This implies that vortioxetine׳s effects on spine and dendritic morphology are mediated by mechanisms that go beyond serotonin reuptake inhibition.

AB - Preclinical studies reveal that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). In the present study, we investigated vortioxetine׳s effects on spines and dendritic morphology in rat hippocampus at two time points compared to the SSRI, fluoxetine. Rats were dosed for 1 and 4 weeks with vortioxetine and fluoxetine at doses relevant for antidepressant activity. Dendritic morphology of pyramidal neurons (i.e., dendritic length, dendritic branch, spine number and density, and Sholl analysis) was examined in Golgi-stained sections from hippocampal CA1. After 1 week of treatment, vortioxetine significantly increased spine number (apical and basal dendrites), spine density (only basal), dendritic length (only apical), and dendritic branch number (apical and basal), whereas fluoxetine had no effect. After 4 weeks of treatment, vortioxetine significantly increased all measures of dendritic spine morphology as did fluoxetine except for spine density of basal dendrites. The number of intersections in the apical and basal dendrites was also significantly increased for both treatments after 4 weeks compared to control. In addition, 4 weeks of vortioxetine treatment, but not fluoxetine, promoted a decrease in spine neck length. In conclusion, 1-week vortioxetine treatment induced changes in spine number and density and dendritic morphology, whereas an equivalent dose of fluoxetine had no effects. Decreased spine neck length following 4-week vortioxetine treatment suggests a transition to mature spine morphology. This implies that vortioxetine׳s effects on spine and dendritic morphology are mediated by mechanisms that go beyond serotonin reuptake inhibition.

U2 - 10.1016/j.euroneuro.2015.12.018

DO - 10.1016/j.euroneuro.2015.12.018

M3 - Journal article

C2 - 26711685

VL - 26

SP - 234

EP - 245

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 2

ER -