Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

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  • Hein Vincent Stroomberg, Rigshospitalet, Denmark
  • Fie Juhl Vojdeman, Deptartment of Clinical Biochemistry, Denmark
  • Christian Medom Madsen, Herlev og Gentofte Hospital
  • ,
  • John Thomas Helgstrand, Rigshospitalet, Denmark
  • Peter Schwarz, Rigshospitalet, Denmark
  • Anne-Marie Heegaard, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark, Denmark
  • Anja Olsen
  • Anne Tjønneland, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Statens Institut for Folkesundhed, Denmark
  • Bent Struer Lind, Hvidovre Hospital, Denmark
  • Klaus Brasso, Rigshospitalet, Denmark
  • Henrik Løvendahl Jørgensen, Hvidovre Hospital, Hvidovre, Denmark
  • Martin Andreas Røder, Rigshospitalet, Denmark

BACKGROUND: Vitamin D has a role in bone turnover and potentially bone-metastatic spread of prostate cancer (PCa). The aim of this observational study was to address the association between levels of serum vitamin D, diagnosis of PCa and subsequent mortality in men who underwent a biopsy of the prostate.

METHODS: All men who underwent prostatic biopsy in the Danish PCa Registry (DaPCaR) and who had a serum vitamin D measurement during the period 2004 to 2010 (n = 4,065) were identified. Men were categorized by clinical cut-offs based on seasonally adjusted serum vitamin D levels in <25 (deficient), 25-50 (insufficient), 50-75 (sufficient) and >75 nmol/L (high) serum vitamin D. Logistic regression model for association between vitamin D and risk of PCa diagnosis and multivariate survival analyses were applied.

RESULTS: No association between serum vitamin D and risk of PCa was found. Overall survival was lowest for serum vitamin D deficiency and a significantly higher PCa specific mortality (HR: 2.37, 95%CI: 1.45-3.90, p < .001) and other cause mortality (HR: 2.08, 95%CI: 1.33-3.24, p = .001) was found for PCa patients with serum vitamin D deficiency compared to serum vitamin D sufficiency.

CONCLUSION: No association was found between serum vitamin D categories and risk of PCa in men who underwent biopsy of the prostate. Men with PCa and serum vitamin D deficiency had a higher overall and PCa specific mortality compared to men with a sufficient level of serum vitamin D.

Original languageEnglish
JournalActa Oncologica
Volume60
Issue3
Pages (from-to)316-322
Number of pages7
ISSN0284-186X
DOIs
Publication statusPublished - Mar 2021

    Research areas

  • prostatic neoplasms, vitamin D, mortality, epidemiology, risk

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