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Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study

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Vitamin B12-fortified toothpaste improves vitamin status in elderly people : a randomized, double-blind, placebo-controlled study. / Zant, Ayman; Awwad, Hussain M; Geisel, Jürgen; Keller, Markus; Obeid, Rima.

In: Aging Clinical and Experimental Research, Vol. 31, No. 12, 12.2019, p. 1817-1825.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Zant, A, Awwad, HM, Geisel, J, Keller, M & Obeid, R 2019, 'Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study', Aging Clinical and Experimental Research, vol. 31, no. 12, pp. 1817-1825. https://doi.org/10.1007/s40520-019-01125-6

APA

Zant, A., Awwad, H. M., Geisel, J., Keller, M., & Obeid, R. (2019). Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study. Aging Clinical and Experimental Research, 31(12), 1817-1825. https://doi.org/10.1007/s40520-019-01125-6

CBE

Zant A, Awwad HM, Geisel J, Keller M, Obeid R. 2019. Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study. Aging Clinical and Experimental Research. 31(12):1817-1825. https://doi.org/10.1007/s40520-019-01125-6

MLA

Vancouver

Zant A, Awwad HM, Geisel J, Keller M, Obeid R. Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study. Aging Clinical and Experimental Research. 2019 Dec;31(12):1817-1825. https://doi.org/10.1007/s40520-019-01125-6

Author

Zant, Ayman ; Awwad, Hussain M ; Geisel, Jürgen ; Keller, Markus ; Obeid, Rima. / Vitamin B12-fortified toothpaste improves vitamin status in elderly people : a randomized, double-blind, placebo-controlled study. In: Aging Clinical and Experimental Research. 2019 ; Vol. 31, No. 12. pp. 1817-1825.

Bibtex

@article{dc5851e9b8264abdb1d0211f30c14a52,
title = "Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study",
abstract = "BACKGROUND: Elderly people are at risk for vitamin B12 deficiency.AIMS: We studied the ability of vitamin B12-enriched toothpaste vs. placebo to increase vitamin B12 status in elderly subjects.METHODS: We conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects. Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months.RESULTS: 92 subjects met the inclusion criteria, completed the 3 months study, and were included in the data analysis. After the intervention, concentrations of vitamin B12 were higher [mean (SD) = 368 (123) vs. 295 (123) pmol/L; p = 0.005] and holoTC tended to be higher [112 (48) vs. 91 (68) pmol/L; p = 0.088] in the vitamin B12 group compared with the placebo group. The changes of serum vitamin B12 [54 (74) vs. 3 (60) pmol/L, p < 0.001], holoTC [21 (34) vs. 2 (32) pmol/L, p = 0.007], and tHcy [- 0.9 (2.3) vs. 0.3 (1.9) µmol/L, p = 0.010] were significantly different between the intervention groups. Mean percentage increase of serum vitamin B12 (+ 23% corresponds to + 54 pmol/L) in the vitamin B12 toothpaste group suggests that the intervention had provided an additional daily intake of approximately + 7 µg oral B12. Common diseases and drugs did not predict the change of blood markers in the vitamin group. No side effects were observed.CONCLUSIONS: The toothpaste enriched with 100 µg cyanocobalamin/g has increased vitamin B12 status and can thus be used for preventing vitamin B12 depletion in elderly people. The trial was registered at ClinicalTrials.gov: NCT02679833.",
keywords = "Elderly, Holotranscobalamin, Supplementation, Vitamin B12 deficiency",
author = "Ayman Zant and Awwad, {Hussain M} and J{\"u}rgen Geisel and Markus Keller and Rima Obeid",
year = "2019",
month = dec,
doi = "10.1007/s40520-019-01125-6",
language = "English",
volume = "31",
pages = "1817--1825",
journal = "Aging Clinical and Experimental Research",
issn = "1594-0667",
publisher = "Editrice/Kurtis s.r.l.",
number = "12",

}

RIS

TY - JOUR

T1 - Vitamin B12-fortified toothpaste improves vitamin status in elderly people

T2 - a randomized, double-blind, placebo-controlled study

AU - Zant, Ayman

AU - Awwad, Hussain M

AU - Geisel, Jürgen

AU - Keller, Markus

AU - Obeid, Rima

PY - 2019/12

Y1 - 2019/12

N2 - BACKGROUND: Elderly people are at risk for vitamin B12 deficiency.AIMS: We studied the ability of vitamin B12-enriched toothpaste vs. placebo to increase vitamin B12 status in elderly subjects.METHODS: We conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects. Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months.RESULTS: 92 subjects met the inclusion criteria, completed the 3 months study, and were included in the data analysis. After the intervention, concentrations of vitamin B12 were higher [mean (SD) = 368 (123) vs. 295 (123) pmol/L; p = 0.005] and holoTC tended to be higher [112 (48) vs. 91 (68) pmol/L; p = 0.088] in the vitamin B12 group compared with the placebo group. The changes of serum vitamin B12 [54 (74) vs. 3 (60) pmol/L, p < 0.001], holoTC [21 (34) vs. 2 (32) pmol/L, p = 0.007], and tHcy [- 0.9 (2.3) vs. 0.3 (1.9) µmol/L, p = 0.010] were significantly different between the intervention groups. Mean percentage increase of serum vitamin B12 (+ 23% corresponds to + 54 pmol/L) in the vitamin B12 toothpaste group suggests that the intervention had provided an additional daily intake of approximately + 7 µg oral B12. Common diseases and drugs did not predict the change of blood markers in the vitamin group. No side effects were observed.CONCLUSIONS: The toothpaste enriched with 100 µg cyanocobalamin/g has increased vitamin B12 status and can thus be used for preventing vitamin B12 depletion in elderly people. The trial was registered at ClinicalTrials.gov: NCT02679833.

AB - BACKGROUND: Elderly people are at risk for vitamin B12 deficiency.AIMS: We studied the ability of vitamin B12-enriched toothpaste vs. placebo to increase vitamin B12 status in elderly subjects.METHODS: We conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects. Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months.RESULTS: 92 subjects met the inclusion criteria, completed the 3 months study, and were included in the data analysis. After the intervention, concentrations of vitamin B12 were higher [mean (SD) = 368 (123) vs. 295 (123) pmol/L; p = 0.005] and holoTC tended to be higher [112 (48) vs. 91 (68) pmol/L; p = 0.088] in the vitamin B12 group compared with the placebo group. The changes of serum vitamin B12 [54 (74) vs. 3 (60) pmol/L, p < 0.001], holoTC [21 (34) vs. 2 (32) pmol/L, p = 0.007], and tHcy [- 0.9 (2.3) vs. 0.3 (1.9) µmol/L, p = 0.010] were significantly different between the intervention groups. Mean percentage increase of serum vitamin B12 (+ 23% corresponds to + 54 pmol/L) in the vitamin B12 toothpaste group suggests that the intervention had provided an additional daily intake of approximately + 7 µg oral B12. Common diseases and drugs did not predict the change of blood markers in the vitamin group. No side effects were observed.CONCLUSIONS: The toothpaste enriched with 100 µg cyanocobalamin/g has increased vitamin B12 status and can thus be used for preventing vitamin B12 depletion in elderly people. The trial was registered at ClinicalTrials.gov: NCT02679833.

KW - Elderly

KW - Holotranscobalamin

KW - Supplementation

KW - Vitamin B12 deficiency

U2 - 10.1007/s40520-019-01125-6

DO - 10.1007/s40520-019-01125-6

M3 - Journal article

C2 - 30680547

VL - 31

SP - 1817

EP - 1825

JO - Aging Clinical and Experimental Research

JF - Aging Clinical and Experimental Research

SN - 1594-0667

IS - 12

ER -