Visualization of thermally activated nanocarriers using in situ atomic force microscopy: Nanotechnology

M. D. Dong; K. A. Howard; D. Oupicky; H. Bisht; Jørgen Kjems; F. Besenbacher

doi:10.1088/0957-4484/18/18/185501

Visualization of thermally activated nanocarriers using in situ atomic force microscopy: Nanotechnology

M. D. Dong, K. A. Howard, D. Oupicky, H. Bisht, Jørgen Kjems, F. Besenbacher

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.

Original language	English
Article number	185501
Journal	Nanotechnology
Volume	18
Issue	18
ISSN	0957-4484
DOIs	https://doi.org/10.1088/0957-4484/18/18/185501
Publication status	Published - 2007

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10.1088/0957-4484/18/18/185501

Cite this

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title = "Visualization of thermally activated nanocarriers using in situ atomic force microscopy: Nanotechnology",

abstract = "Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.",

author = "Dong, {M. D.} and Howard, {K. A.} and D. Oupicky and H. Bisht and J{\o}rgen Kjems and F. Besenbacher",

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AU - Kjems, Jørgen

AU - Besenbacher, F.

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AB - Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.

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