Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • James T Grist, University of Cambridge
  • ,
  • Frank Riemer, University of Cambridge
  • ,
  • Esben Hansen
  • Rasmus S Tougaard
  • Mary A McLean, University of Cambridge
  • ,
  • Joshua Kaggie, University of Cambridge
  • ,
  • Nikolaj Bøgh
  • Martin J Graves, Cambridge University Hospitals NHS Foundation Trust
  • ,
  • Ferdia A Gallagher, University of Cambridge
  • ,
  • Christoffer Laustsen

Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess the sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and was independent of blood electrolyte measurements. Thus, rapid sodium MRI can be used to dynamically quantify sodium biodistribution in the porcine and human kidney.

Original languageEnglish
Book seriesKidney International
Volume98
Issue5
Pages (from-to)1174-1178
Number of pages5
ISSN0085-2538
DOIs
Publication statusPublished - Nov 2020

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