Visualization of sodium dynamics in the kidney by magnetic resonance imaging by a multisite study

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  • James T Grist, Department of Radiology, University of Cambridge and Addenbrooke’s Hospital, Cambridge
  • ,
  • Frank Riemer, Department of Radiology, University of Cambridge and Addenbrooke’s Hospital, Cambridge
  • ,
  • Esben Hansen
  • Rasmus S Tougaard
  • Mary A McLean, Department of Radiology, University of Cambridge and Addenbrooke’s Hospital, Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, University of Cambridge
  • ,
  • Joshua Kaggie, Department of Radiology, University of Cambridge and Addenbrooke’s Hospital, Cambridge
  • ,
  • Nikolaj Bøgh
  • Martin J Graves, Cambridge University Hospitals NHS Foundation Trust
  • ,
  • Ferdia A Gallagher, Department of Radiology, University of Cambridge and Addenbrooke’s Hospital, Cambridge
  • ,
  • Christoffer Laustsen

Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess the sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and was independent of blood electrolyte measurements. Thus, rapid sodium MRI can be used to dynamically quantify sodium biodistribution in the porcine and human kidney.

Original languageEnglish
Title of host publicationVisualization of sodium dynamics in the kidney by magnetic resonance imaging by a multisite study
DOIs
Publication statusE-pub ahead of print - 22 Jun 2020
SeriesKidney International
ISSN0085-2538

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