Viral recognition and the antiviral interferon response

Louise Dalskov; Hans Henrik Gad; Rune Hartmann

doi:10.15252/embj.2022112907

Viral recognition and the antiviral interferon response

Louise Dalskov, Hans Henrik Gad, Rune Hartmann^*

^*Corresponding author for this work

Department of Molecular Biology and Genetics - RNA Biology and Innovation

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

33 Citations (Scopus)

Abstract

Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. Many of these gene products either combat the viral infection directly, e.g., by interfering with viral replication, or help shape the following immune response. Here, we review how viral recognition leads to the production of different types of IFNs and how this production differs in spatial and temporal manners. We then continue to describe how these IFNs play different roles in the ensuing immune response depending on when and where they are produced or act during an infection.

Original language	English
Article number	e112907
Journal	EMBO Journal
Volume	42
Issue	14
Number of pages	11
ISSN	0261-4189
DOIs	https://doi.org/10.15252/embj.2022112907
Publication status	Published - Jul 2023

Keywords

Interferon
Interferon Regulatory Factor 3 (IRF3)
Interferon induction
viral recognition
Virus Diseases/drug therapy
Interferon Regulatory Factor-3/metabolism
Cytokines
Interferons
Humans
Antiviral Agents/pharmacology
Immunity, Innate

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title = "Viral recognition and the antiviral interferon response",

abstract = "Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. Many of these gene products either combat the viral infection directly, e.g., by interfering with viral replication, or help shape the following immune response. Here, we review how viral recognition leads to the production of different types of IFNs and how this production differs in spatial and temporal manners. We then continue to describe how these IFNs play different roles in the ensuing immune response depending on when and where they are produced or act during an infection.",

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author = "Louise Dalskov and Gad, {Hans Henrik} and Rune Hartmann",

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doi = "10.15252/embj.2022112907",

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AU - Dalskov, Louise

AU - Gad, Hans Henrik

AU - Hartmann, Rune

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AB - Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. Many of these gene products either combat the viral infection directly, e.g., by interfering with viral replication, or help shape the following immune response. Here, we review how viral recognition leads to the production of different types of IFNs and how this production differs in spatial and temporal manners. We then continue to describe how these IFNs play different roles in the ensuing immune response depending on when and where they are produced or act during an infection.

KW - Interferon

KW - Interferon Regulatory Factor 3 (IRF3)

KW - Interferon induction

KW - viral recognition

KW - Virus Diseases/drug therapy

KW - Interferon Regulatory Factor-3/metabolism

KW - Cytokines

KW - Interferons

KW - Humans

KW - Antiviral Agents/pharmacology

KW - Immunity, Innate

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DO - 10.15252/embj.2022112907

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VL - 42

JO - EMBO Journal

JF - EMBO Journal

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ER -

Viral recognition and the antiviral interferon response

Abstract

Keywords

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