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Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility

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Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. / Tomac, Jelena; Mazor, Marija; Lisnić, Berislav; Golemac, Mijo; Kveštak, Daria; Bralić, Marina; Bilić Zulle, Lidija; Brinkmann, Melanie M.; Dölken, Lars; Reinert, Line S.; Paludan, Soren R.; Krmpotić, Astrid; Jonjić, Stipan; Juranić Lisnić, Vanda.

In: Immunity, Vol. 54, No. 7, 07.2021, p. 1478-1493.e6.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Tomac, J, Mazor, M, Lisnić, B, Golemac, M, Kveštak, D, Bralić, M, Bilić Zulle, L, Brinkmann, MM, Dölken, L, Reinert, LS, Paludan, SR, Krmpotić, A, Jonjić, S & Juranić Lisnić, V 2021, 'Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility', Immunity, vol. 54, no. 7, pp. 1478-1493.e6. https://doi.org/10.1016/j.immuni.2021.04.020

APA

Tomac, J., Mazor, M., Lisnić, B., Golemac, M., Kveštak, D., Bralić, M., Bilić Zulle, L., Brinkmann, M. M., Dölken, L., Reinert, L. S., Paludan, S. R., Krmpotić, A., Jonjić, S., & Juranić Lisnić, V. (2021). Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity, 54(7), 1478-1493.e6. https://doi.org/10.1016/j.immuni.2021.04.020

CBE

Tomac J, Mazor M, Lisnić B, Golemac M, Kveštak D, Bralić M, Bilić Zulle L, Brinkmann MM, Dölken L, Reinert LS, Paludan SR, Krmpotić A, Jonjić S, Juranić Lisnić V. 2021. Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity. 54(7):1478-1493.e6. https://doi.org/10.1016/j.immuni.2021.04.020

MLA

Vancouver

Tomac J, Mazor M, Lisnić B, Golemac M, Kveštak D, Bralić M et al. Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity. 2021 Jul;54(7):1478-1493.e6. https://doi.org/10.1016/j.immuni.2021.04.020

Author

Tomac, Jelena ; Mazor, Marija ; Lisnić, Berislav ; Golemac, Mijo ; Kveštak, Daria ; Bralić, Marina ; Bilić Zulle, Lidija ; Brinkmann, Melanie M. ; Dölken, Lars ; Reinert, Line S. ; Paludan, Soren R. ; Krmpotić, Astrid ; Jonjić, Stipan ; Juranić Lisnić, Vanda. / Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. In: Immunity. 2021 ; Vol. 54, No. 7. pp. 1478-1493.e6.

Bibtex

@article{dbfc3085586241bfbd018927f2d5e255,
title = "Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility",
abstract = "Viral infections during pregnancy are a considerable cause of adverse outcomes and birth defects, and the underlying mechanisms are poorly understood. Among those, cytomegalovirus (CMV) infection stands out as the most common intrauterine infection in humans, putatively causing early pregnancy loss. We employed murine CMV as a model to study the consequences of viral infection on pregnancy outcome and fertility maintenance. Even though pregnant mice successfully controlled CMV infection, we observed highly selective, strong infection of corpus luteum (CL) cells in their ovaries. High infection densities indicated complete failure of immune control in CL cells, resulting in progesterone insufficiency and pregnancy loss. An abundance of gap junctions, absence of vasculature, strong type I interferon (IFN) responses, and interaction of innate immune cells fully protected the ovarian follicles from viral infection. Our work provides fundamental insights into the effect of CMV infection on pregnancy loss and mechanisms protecting fertility.",
keywords = "CMV, corpus luteum, cytomegalovirus, fertility, follicles, innate immunity, interferon, macrophages, NK cells, pregnancy loss, virus",
author = "Jelena Tomac and Marija Mazor and Berislav Lisni{\'c} and Mijo Golemac and Daria Kve{\v s}tak and Marina Brali{\'c} and {Bili{\'c} Zulle}, Lidija and Brinkmann, {Melanie M.} and Lars D{\"o}lken and Reinert, {Line S.} and Paludan, {Soren R.} and Astrid Krmpoti{\'c} and Stipan Jonji{\'c} and {Jurani{\'c} Lisni{\'c}}, Vanda",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = jul,
doi = "10.1016/j.immuni.2021.04.020",
language = "English",
volume = "54",
pages = "1478--1493.e6",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility

AU - Tomac, Jelena

AU - Mazor, Marija

AU - Lisnić, Berislav

AU - Golemac, Mijo

AU - Kveštak, Daria

AU - Bralić, Marina

AU - Bilić Zulle, Lidija

AU - Brinkmann, Melanie M.

AU - Dölken, Lars

AU - Reinert, Line S.

AU - Paludan, Soren R.

AU - Krmpotić, Astrid

AU - Jonjić, Stipan

AU - Juranić Lisnić, Vanda

N1 - Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/7

Y1 - 2021/7

N2 - Viral infections during pregnancy are a considerable cause of adverse outcomes and birth defects, and the underlying mechanisms are poorly understood. Among those, cytomegalovirus (CMV) infection stands out as the most common intrauterine infection in humans, putatively causing early pregnancy loss. We employed murine CMV as a model to study the consequences of viral infection on pregnancy outcome and fertility maintenance. Even though pregnant mice successfully controlled CMV infection, we observed highly selective, strong infection of corpus luteum (CL) cells in their ovaries. High infection densities indicated complete failure of immune control in CL cells, resulting in progesterone insufficiency and pregnancy loss. An abundance of gap junctions, absence of vasculature, strong type I interferon (IFN) responses, and interaction of innate immune cells fully protected the ovarian follicles from viral infection. Our work provides fundamental insights into the effect of CMV infection on pregnancy loss and mechanisms protecting fertility.

AB - Viral infections during pregnancy are a considerable cause of adverse outcomes and birth defects, and the underlying mechanisms are poorly understood. Among those, cytomegalovirus (CMV) infection stands out as the most common intrauterine infection in humans, putatively causing early pregnancy loss. We employed murine CMV as a model to study the consequences of viral infection on pregnancy outcome and fertility maintenance. Even though pregnant mice successfully controlled CMV infection, we observed highly selective, strong infection of corpus luteum (CL) cells in their ovaries. High infection densities indicated complete failure of immune control in CL cells, resulting in progesterone insufficiency and pregnancy loss. An abundance of gap junctions, absence of vasculature, strong type I interferon (IFN) responses, and interaction of innate immune cells fully protected the ovarian follicles from viral infection. Our work provides fundamental insights into the effect of CMV infection on pregnancy loss and mechanisms protecting fertility.

KW - CMV

KW - corpus luteum

KW - cytomegalovirus

KW - fertility

KW - follicles

KW - innate immunity

KW - interferon

KW - macrophages

KW - NK cells

KW - pregnancy loss

KW - virus

UR - http://www.scopus.com/inward/record.url?scp=85107306407&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2021.04.020

DO - 10.1016/j.immuni.2021.04.020

M3 - Journal article

C2 - 34015257

AN - SCOPUS:85107306407

VL - 54

SP - 1478-1493.e6

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 7

ER -