Department of Economics and Business Economics

Vascular Pathology and Trajectories of Late-Life Major Depressive Disorder in Secondary Psychiatric Care

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Vascular Pathology and Trajectories of Late-Life Major Depressive Disorder in Secondary Psychiatric Care. / Musliner, Katherine L; Zandi, Peter P; Liu, Xiaoqin; Laursen, Thomas M; Munk-Olsen, Trine; Mortensen, Preben B; Eaton, William W.

In: The American Journal of Geriatric Psychiatry, Vol. 26, No. 3, 2018, p. 386-395.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{0e280b000bc94e26b32af75c86ec3db2,
title = "Vascular Pathology and Trajectories of Late-Life Major Depressive Disorder in Secondary Psychiatric Care",
abstract = "OBJECTIVE: To examine 5-year trajectories of psychiatrist-treated late-life major depressive disorder (MDD), and evaluate whether previous vascular pathology is associated with more severe trajectories of late-life MDD.METHODS: Data were obtained from nationally representative civil, psychiatric, hospital, and prescription registers in Denmark. The sample included 11,092 older adults (≥60 years) who received their first diagnosis of MDD in a psychiatric facility in Denmark between 2000 and 2007. Trajectories of inpatient or outpatient contact at psychiatric hospitals for MDD over the 5-year period following index MDD diagnosis were modeled using latent class growth analysis. Measures of vascular disease (stroke, heart disease, vascular dementia) and vascular risk factors (hypertension, diabetes) were defined based on medication prescriptions and hospital-based diagnoses. Other predictors included demographic characteristics and characteristics of the index MDD diagnosis.RESULTS: The final model included 4 trajectories with consistently low (66% of the sample), high decreasing (19%), consistently high (9%), and moderate fluctuating (6%) probabilities of contact at a psychiatric hospital for MDD during the 5-year period following the index MDD diagnosis. We found no significant associations between any form of vascular pathology and trajectory class membership. Relative to the consistently low class, older age, greater severity and >12 months of prior antidepressant medication use predicted membership in the other three classes.CONCLUSIONS: A notable proportion (34%) of individuals diagnosed with MDD in late-life require secondary psychiatric treatment for extended time periods. We did not find evidence that vascular pathology predicts hospital contact trajectories in secondary-treated late-life MDD.",
keywords = "Journal Article, CIVIL REGISTRATION SYSTEM, DEVELOPMENTAL TRAJECTORIES, POPULATION, REGISTER, SAS PROCEDURE, RISK-FACTORS, trajectories, NATURAL-HISTORY, vascular disease, Major depression, DISEASE, HYPOTHESIS, COHORT, vascular risk factors, Follow-Up Studies, Humans, Middle Aged, Male, Registries/statistics & numerical data, Aged, 80 and over, Female, Hospitals, Psychiatric/statistics & numerical data, Depressive Disorder, Major/classification, Patient Admission/statistics & numerical data, Comorbidity, Risk Factors, Secondary Care/statistics & numerical data, Denmark/epidemiology, Vascular Diseases/epidemiology, Aged",
author = "Musliner, {Katherine L} and Zandi, {Peter P} and Xiaoqin Liu and Laursen, {Thomas M} and Trine Munk-Olsen and Mortensen, {Preben B} and Eaton, {William W}",
note = "Copyright {\textcopyright} 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2018",
doi = "10.1016/j.jagp.2017.07.006",
language = "English",
volume = "26",
pages = "386--395",
journal = "The American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Vascular Pathology and Trajectories of Late-Life Major Depressive Disorder in Secondary Psychiatric Care

AU - Musliner, Katherine L

AU - Zandi, Peter P

AU - Liu, Xiaoqin

AU - Laursen, Thomas M

AU - Munk-Olsen, Trine

AU - Mortensen, Preben B

AU - Eaton, William W

N1 - Copyright © 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: To examine 5-year trajectories of psychiatrist-treated late-life major depressive disorder (MDD), and evaluate whether previous vascular pathology is associated with more severe trajectories of late-life MDD.METHODS: Data were obtained from nationally representative civil, psychiatric, hospital, and prescription registers in Denmark. The sample included 11,092 older adults (≥60 years) who received their first diagnosis of MDD in a psychiatric facility in Denmark between 2000 and 2007. Trajectories of inpatient or outpatient contact at psychiatric hospitals for MDD over the 5-year period following index MDD diagnosis were modeled using latent class growth analysis. Measures of vascular disease (stroke, heart disease, vascular dementia) and vascular risk factors (hypertension, diabetes) were defined based on medication prescriptions and hospital-based diagnoses. Other predictors included demographic characteristics and characteristics of the index MDD diagnosis.RESULTS: The final model included 4 trajectories with consistently low (66% of the sample), high decreasing (19%), consistently high (9%), and moderate fluctuating (6%) probabilities of contact at a psychiatric hospital for MDD during the 5-year period following the index MDD diagnosis. We found no significant associations between any form of vascular pathology and trajectory class membership. Relative to the consistently low class, older age, greater severity and >12 months of prior antidepressant medication use predicted membership in the other three classes.CONCLUSIONS: A notable proportion (34%) of individuals diagnosed with MDD in late-life require secondary psychiatric treatment for extended time periods. We did not find evidence that vascular pathology predicts hospital contact trajectories in secondary-treated late-life MDD.

AB - OBJECTIVE: To examine 5-year trajectories of psychiatrist-treated late-life major depressive disorder (MDD), and evaluate whether previous vascular pathology is associated with more severe trajectories of late-life MDD.METHODS: Data were obtained from nationally representative civil, psychiatric, hospital, and prescription registers in Denmark. The sample included 11,092 older adults (≥60 years) who received their first diagnosis of MDD in a psychiatric facility in Denmark between 2000 and 2007. Trajectories of inpatient or outpatient contact at psychiatric hospitals for MDD over the 5-year period following index MDD diagnosis were modeled using latent class growth analysis. Measures of vascular disease (stroke, heart disease, vascular dementia) and vascular risk factors (hypertension, diabetes) were defined based on medication prescriptions and hospital-based diagnoses. Other predictors included demographic characteristics and characteristics of the index MDD diagnosis.RESULTS: The final model included 4 trajectories with consistently low (66% of the sample), high decreasing (19%), consistently high (9%), and moderate fluctuating (6%) probabilities of contact at a psychiatric hospital for MDD during the 5-year period following the index MDD diagnosis. We found no significant associations between any form of vascular pathology and trajectory class membership. Relative to the consistently low class, older age, greater severity and >12 months of prior antidepressant medication use predicted membership in the other three classes.CONCLUSIONS: A notable proportion (34%) of individuals diagnosed with MDD in late-life require secondary psychiatric treatment for extended time periods. We did not find evidence that vascular pathology predicts hospital contact trajectories in secondary-treated late-life MDD.

KW - Journal Article

KW - CIVIL REGISTRATION SYSTEM

KW - DEVELOPMENTAL TRAJECTORIES

KW - POPULATION

KW - REGISTER

KW - SAS PROCEDURE

KW - RISK-FACTORS

KW - trajectories

KW - NATURAL-HISTORY

KW - vascular disease

KW - Major depression

KW - DISEASE

KW - HYPOTHESIS

KW - COHORT

KW - vascular risk factors

KW - Follow-Up Studies

KW - Humans

KW - Middle Aged

KW - Male

KW - Registries/statistics & numerical data

KW - Aged, 80 and over

KW - Female

KW - Hospitals, Psychiatric/statistics & numerical data

KW - Depressive Disorder, Major/classification

KW - Patient Admission/statistics & numerical data

KW - Comorbidity

KW - Risk Factors

KW - Secondary Care/statistics & numerical data

KW - Denmark/epidemiology

KW - Vascular Diseases/epidemiology

KW - Aged

UR - http://www.scopus.com/inward/record.url?scp=85028330057&partnerID=8YFLogxK

U2 - 10.1016/j.jagp.2017.07.006

DO - 10.1016/j.jagp.2017.07.006

M3 - Journal article

C2 - 28807498

VL - 26

SP - 386

EP - 395

JO - The American Journal of Geriatric Psychiatry

JF - The American Journal of Geriatric Psychiatry

SN - 1064-7481

IS - 3

ER -