Department of Economics and Business Economics

Vascular Pathology and Trajectories of Late-Life Major Depressive Disorder in Secondary Psychiatric Care

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OBJECTIVE: To examine 5-year trajectories of psychiatrist-treated late-life major depressive disorder (MDD), and evaluate whether previous vascular pathology is associated with more severe trajectories of late-life MDD.

METHODS: Data were obtained from nationally representative civil, psychiatric, hospital, and prescription registers in Denmark. The sample included 11,092 older adults (≥60 years) who received their first diagnosis of MDD in a psychiatric facility in Denmark between 2000 and 2007. Trajectories of inpatient or outpatient contact at psychiatric hospitals for MDD over the 5-year period following index MDD diagnosis were modeled using latent class growth analysis. Measures of vascular disease (stroke, heart disease, vascular dementia) and vascular risk factors (hypertension, diabetes) were defined based on medication prescriptions and hospital-based diagnoses. Other predictors included demographic characteristics and characteristics of the index MDD diagnosis.

RESULTS: The final model included 4 trajectories with consistently low (66% of the sample), high decreasing (19%), consistently high (9%), and moderate fluctuating (6%) probabilities of contact at a psychiatric hospital for MDD during the 5-year period following the index MDD diagnosis. We found no significant associations between any form of vascular pathology and trajectory class membership. Relative to the consistently low class, older age, greater severity and >12 months of prior antidepressant medication use predicted membership in the other three classes.

CONCLUSIONS: A notable proportion (34%) of individuals diagnosed with MDD in late-life require secondary psychiatric treatment for extended time periods. We did not find evidence that vascular pathology predicts hospital contact trajectories in secondary-treated late-life MDD.

Original languageEnglish
JournalThe American Journal of Geriatric Psychiatry
Pages (from-to)386-395
Number of pages10
Publication statusPublished - 2018

    Research areas

  • Journal Article, CIVIL REGISTRATION SYSTEM, DEVELOPMENTAL TRAJECTORIES, POPULATION, REGISTER, SAS PROCEDURE, RISK-FACTORS, trajectories, NATURAL-HISTORY, vascular disease, Major depression, DISEASE, HYPOTHESIS, COHORT, vascular risk factors, Follow-Up Studies, Humans, Middle Aged, Male, Registries/statistics & numerical data, Aged, 80 and over, Female, Hospitals, Psychiatric/statistics & numerical data, Depressive Disorder, Major/classification, Patient Admission/statistics & numerical data, Comorbidity, Risk Factors, Secondary Care/statistics & numerical data, Denmark/epidemiology, Vascular Diseases/epidemiology, Aged

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