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Variations on a theme: Crystal forms of the amino-acid transporter MhsT

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The bacterial amino-acid transporter MhsT from the SLC6A family has been crystallized in complex with different substrates in order to understand the determinants of the substrate specificity of the transporter. Surprisingly, crystals of the different MhsT-substrate complexes showed interrelated but different crystal-packing arrangements. Space-group assignment and structure determination of these different crystal forms present challenging combinations of pseudosymmetry, twinning and translational noncrystallographic symmetry.

Original languageEnglish
JournalActa Crystallographica Section F: Structural Biology Communications
IssuePart 8
Pages (from-to)297-305
Number of pages9
Publication statusPublished - Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 International Union of Crystallography. All rights reserved.

    Research areas

  • bacterial amino-acid transporters, membrane proteins, MhsT, pseudomerohedral twinning, pseudosymmetry, translational NCS, translational symmetry, X-ray crystallography

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