Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS). / Sundin, Ulf; Østergaard, Mikkel; Glinatsi, Daniel; Aga, Anna Birgitte; Hørslev-Petersen, Kim; Hetland, Merete L.; Stengaard-Pedersen, Kristian; Junker, Peter; Ejbjerg, Bo J.; Bird, Paul; Conaghan, Philip G.; Lillegraven, Siri; Haavardsholm, Espen A.

In: Journal of Rheumatology, Vol. 46, No. 9, 2019, p. 1222-1227.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Sundin, U, Østergaard, M, Glinatsi, D, Aga, AB, Hørslev-Petersen, K, Hetland, ML, Stengaard-Pedersen, K, Junker, P, Ejbjerg, BJ, Bird, P, Conaghan, PG, Lillegraven, S & Haavardsholm, EA 2019, 'Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS)', Journal of Rheumatology, vol. 46, no. 9, pp. 1222-1227. https://doi.org/10.3899/jrheum.181064

APA

Sundin, U., Østergaard, M., Glinatsi, D., Aga, A. B., Hørslev-Petersen, K., Hetland, M. L., ... Haavardsholm, E. A. (2019). Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS). Journal of Rheumatology, 46(9), 1222-1227. https://doi.org/10.3899/jrheum.181064

CBE

Sundin U, Østergaard M, Glinatsi D, Aga AB, Hørslev-Petersen K, Hetland ML, Stengaard-Pedersen K, Junker P, Ejbjerg BJ, Bird P, Conaghan PG, Lillegraven S, Haavardsholm EA. 2019. Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS). Journal of Rheumatology. 46(9):1222-1227. https://doi.org/10.3899/jrheum.181064

MLA

Vancouver

Sundin U, Østergaard M, Glinatsi D, Aga AB, Hørslev-Petersen K, Hetland ML et al. Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS). Journal of Rheumatology. 2019;46(9):1222-1227. https://doi.org/10.3899/jrheum.181064

Author

Sundin, Ulf ; Østergaard, Mikkel ; Glinatsi, Daniel ; Aga, Anna Birgitte ; Hørslev-Petersen, Kim ; Hetland, Merete L. ; Stengaard-Pedersen, Kristian ; Junker, Peter ; Ejbjerg, Bo J. ; Bird, Paul ; Conaghan, Philip G. ; Lillegraven, Siri ; Haavardsholm, Espen A. / Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS). In: Journal of Rheumatology. 2019 ; Vol. 46, No. 9. pp. 1222-1227.

Bibtex

@article{49f517e323d540158147ad6863b2b60f,
title = "Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS)",
abstract = "Objective. The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage. Methods. We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Methods included unweighted summation, normalized summation, and 3 different variants of weighted summation of the RAMRIS features. We used a derivation cohort to calculate summation weights to maximize the responsiveness of the combined score. Construct validity of the combined scores was examined by assessing correlations to imaging, clinical, and biochemical measures. Responsiveness was tested by calculating the standardized response mean (SRM) and the relative efficiency of each score in a validation cohort. Results. Patient characteristics, as well as baseline and followup RAMRIS scores, were comparable between cohorts. All combined scores were significantly correlated to other imaging, clinical, and biochemical measures. Inflammation scores combined by normalized and weighted summation had significantly higher responsiveness in comparison to unweighted summation, with SRM (95{\%} CI) for unweighted summation 0.62 (0.51-0.73), normalized summation 0.73 (0.63-0.83), and weighted summation 0.74 (0.64-0.84). For the damage score, there was a trend toward higher responsiveness for weighted summation. Conclusion. Combined MRI scores calculated by normalized or weighted summation of individual MRI pathologies were valid and responsive.",
keywords = "Clinical trials, Magnetic resonance imaging, Omeract, Outcome assessment, Rheumatoid arthritis",
author = "Ulf Sundin and Mikkel {\O}stergaard and Daniel Glinatsi and Aga, {Anna Birgitte} and Kim H{\o}rslev-Petersen and Hetland, {Merete L.} and Kristian Stengaard-Pedersen and Peter Junker and Ejbjerg, {Bo J.} and Paul Bird and Conaghan, {Philip G.} and Siri Lillegraven and Haavardsholm, {Espen A.}",
year = "2019",
doi = "10.3899/jrheum.181064",
language = "English",
volume = "46",
pages = "1222--1227",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS)

AU - Sundin, Ulf

AU - Østergaard, Mikkel

AU - Glinatsi, Daniel

AU - Aga, Anna Birgitte

AU - Hørslev-Petersen, Kim

AU - Hetland, Merete L.

AU - Stengaard-Pedersen, Kristian

AU - Junker, Peter

AU - Ejbjerg, Bo J.

AU - Bird, Paul

AU - Conaghan, Philip G.

AU - Lillegraven, Siri

AU - Haavardsholm, Espen A.

PY - 2019

Y1 - 2019

N2 - Objective. The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage. Methods. We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Methods included unweighted summation, normalized summation, and 3 different variants of weighted summation of the RAMRIS features. We used a derivation cohort to calculate summation weights to maximize the responsiveness of the combined score. Construct validity of the combined scores was examined by assessing correlations to imaging, clinical, and biochemical measures. Responsiveness was tested by calculating the standardized response mean (SRM) and the relative efficiency of each score in a validation cohort. Results. Patient characteristics, as well as baseline and followup RAMRIS scores, were comparable between cohorts. All combined scores were significantly correlated to other imaging, clinical, and biochemical measures. Inflammation scores combined by normalized and weighted summation had significantly higher responsiveness in comparison to unweighted summation, with SRM (95% CI) for unweighted summation 0.62 (0.51-0.73), normalized summation 0.73 (0.63-0.83), and weighted summation 0.74 (0.64-0.84). For the damage score, there was a trend toward higher responsiveness for weighted summation. Conclusion. Combined MRI scores calculated by normalized or weighted summation of individual MRI pathologies were valid and responsive.

AB - Objective. The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage. Methods. We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Methods included unweighted summation, normalized summation, and 3 different variants of weighted summation of the RAMRIS features. We used a derivation cohort to calculate summation weights to maximize the responsiveness of the combined score. Construct validity of the combined scores was examined by assessing correlations to imaging, clinical, and biochemical measures. Responsiveness was tested by calculating the standardized response mean (SRM) and the relative efficiency of each score in a validation cohort. Results. Patient characteristics, as well as baseline and followup RAMRIS scores, were comparable between cohorts. All combined scores were significantly correlated to other imaging, clinical, and biochemical measures. Inflammation scores combined by normalized and weighted summation had significantly higher responsiveness in comparison to unweighted summation, with SRM (95% CI) for unweighted summation 0.62 (0.51-0.73), normalized summation 0.73 (0.63-0.83), and weighted summation 0.74 (0.64-0.84). For the damage score, there was a trend toward higher responsiveness for weighted summation. Conclusion. Combined MRI scores calculated by normalized or weighted summation of individual MRI pathologies were valid and responsive.

KW - Clinical trials

KW - Magnetic resonance imaging

KW - Omeract

KW - Outcome assessment

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=85071749742&partnerID=8YFLogxK

U2 - 10.3899/jrheum.181064

DO - 10.3899/jrheum.181064

M3 - Journal article

C2 - 30770509

AN - SCOPUS:85071749742

VL - 46

SP - 1222

EP - 1227

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 9

ER -