Department of Economics and Business Economics

Vaccination against SARS-CoV-2 infection among vulnerable and marginalised population groups in Denmark: A nationwide population-based study

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Vaccination against SARS-CoV-2 infection among vulnerable and marginalised population groups in Denmark : A nationwide population-based study. / Nilsson, Sandra Feodor; Laursen, Thomas Munk; Osler, Merete et al.

In: The Lancet Regional Health - Europe, Vol. 16, 100355, 05.2022.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Nilsson, SF, Laursen, TM, Osler, M, Hjorthøj, C, Benros, ME, Ethelberg, S, Mølbak, K & Nordentoft, M 2022, 'Vaccination against SARS-CoV-2 infection among vulnerable and marginalised population groups in Denmark: A nationwide population-based study', The Lancet Regional Health - Europe, vol. 16, 100355. https://doi.org/10.1016/j.lanepe.2022.100355

APA

Nilsson, S. F., Laursen, T. M., Osler, M., Hjorthøj, C., Benros, M. E., Ethelberg, S., Mølbak, K., & Nordentoft, M. (2022). Vaccination against SARS-CoV-2 infection among vulnerable and marginalised population groups in Denmark: A nationwide population-based study. The Lancet Regional Health - Europe, 16, [100355]. https://doi.org/10.1016/j.lanepe.2022.100355

CBE

Nilsson SF, Laursen TM, Osler M, Hjorthøj C, Benros ME, Ethelberg S, Mølbak K, Nordentoft M. 2022. Vaccination against SARS-CoV-2 infection among vulnerable and marginalised population groups in Denmark: A nationwide population-based study. The Lancet Regional Health - Europe. 16:Article 100355. https://doi.org/10.1016/j.lanepe.2022.100355

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@article{dcbd1aa9be1a4f15b984dee67fca045e,
title = "Vaccination against SARS-CoV-2 infection among vulnerable and marginalised population groups in Denmark: A nationwide population-based study",
abstract = "Background: Social deprivation, psychiatric and medical disorders have been associated with increased risk of infection and severe COVID-19-related health problems. We aimed to study the rates of SARS-CoV-2 vaccination in these high-risk groups. Methods: Using health, vaccination, and administrative registers, we performed a population-based cohort study including all Danish residents aged at least 15 years, December 27, 2020, to October 15, 2021. Population groups were people experiencing: (1) homelessness, (2) imprisonment, (3) substance abuse, (4) severe mental illness, (5) supported psychiatric housing, (6) psychiatric admission, and (7) chronic medical condition. The outcome was vaccine uptake of two doses against SARS-CoV-2 infection. We calculated cumulative vaccine uptake and adjusted vaccination incidence rate ratios (IRRs) relative to the general population by sex and population group. Findings: The cohort included 4,935,344 individuals, of whom 4,277,380 (86·7%) received two doses of vaccine. Lower cumulative vaccine uptake was found for all socially deprived and psychiatrically vulnerable population groups compared with the general population. Lowest uptake was found for people below 65 years experiencing homelessness (54·6%, 95% confidence interval (CI) 53·4-55·8, p<0·0001). After adjustment for age and calendar time, homelessness was associated with markedly lower rates of vaccine uptake (IRR 0·5, 95% CI 0·5-0·6 in males and 0·4, 0·4-0·5 in females) with similar results for imprisonment. Lower vaccine uptake was also found for most of the psychiatric groups with the lower IRR for substance abuse (IRR 0·7, 0·7–0·7 in males and 0·8, 0·8-0·8 in females). Individuals with new-onset severe mental illness and, especially, those in supported psychiatric housing and with chronic medical conditions had the highest vaccine uptake among the studied population groups. Interpretation: Especially, socially deprived population groups, but also individuals with psychiatric vulnerability need higher priority in the implementation of the vaccination strategy to increase equity in immunization uptake. Funding: Novo Nordisk Foundation.",
author = "Nilsson, {Sandra Feodor} and Laursen, {Thomas Munk} and Merete Osler and Carsten Hjorth{\o}j and Benros, {Michael E.} and Steen Ethelberg and K{\aa}re M{\o}lbak and Merete Nordentoft",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = may,
doi = "10.1016/j.lanepe.2022.100355",
language = "English",
volume = "16",
journal = "The Lancet Regional Health - Europe",
issn = "2666-7762",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Vaccination against SARS-CoV-2 infection among vulnerable and marginalised population groups in Denmark

T2 - A nationwide population-based study

AU - Nilsson, Sandra Feodor

AU - Laursen, Thomas Munk

AU - Osler, Merete

AU - Hjorthøj, Carsten

AU - Benros, Michael E.

AU - Ethelberg, Steen

AU - Mølbak, Kåre

AU - Nordentoft, Merete

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022/5

Y1 - 2022/5

N2 - Background: Social deprivation, psychiatric and medical disorders have been associated with increased risk of infection and severe COVID-19-related health problems. We aimed to study the rates of SARS-CoV-2 vaccination in these high-risk groups. Methods: Using health, vaccination, and administrative registers, we performed a population-based cohort study including all Danish residents aged at least 15 years, December 27, 2020, to October 15, 2021. Population groups were people experiencing: (1) homelessness, (2) imprisonment, (3) substance abuse, (4) severe mental illness, (5) supported psychiatric housing, (6) psychiatric admission, and (7) chronic medical condition. The outcome was vaccine uptake of two doses against SARS-CoV-2 infection. We calculated cumulative vaccine uptake and adjusted vaccination incidence rate ratios (IRRs) relative to the general population by sex and population group. Findings: The cohort included 4,935,344 individuals, of whom 4,277,380 (86·7%) received two doses of vaccine. Lower cumulative vaccine uptake was found for all socially deprived and psychiatrically vulnerable population groups compared with the general population. Lowest uptake was found for people below 65 years experiencing homelessness (54·6%, 95% confidence interval (CI) 53·4-55·8, p<0·0001). After adjustment for age and calendar time, homelessness was associated with markedly lower rates of vaccine uptake (IRR 0·5, 95% CI 0·5-0·6 in males and 0·4, 0·4-0·5 in females) with similar results for imprisonment. Lower vaccine uptake was also found for most of the psychiatric groups with the lower IRR for substance abuse (IRR 0·7, 0·7–0·7 in males and 0·8, 0·8-0·8 in females). Individuals with new-onset severe mental illness and, especially, those in supported psychiatric housing and with chronic medical conditions had the highest vaccine uptake among the studied population groups. Interpretation: Especially, socially deprived population groups, but also individuals with psychiatric vulnerability need higher priority in the implementation of the vaccination strategy to increase equity in immunization uptake. Funding: Novo Nordisk Foundation.

AB - Background: Social deprivation, psychiatric and medical disorders have been associated with increased risk of infection and severe COVID-19-related health problems. We aimed to study the rates of SARS-CoV-2 vaccination in these high-risk groups. Methods: Using health, vaccination, and administrative registers, we performed a population-based cohort study including all Danish residents aged at least 15 years, December 27, 2020, to October 15, 2021. Population groups were people experiencing: (1) homelessness, (2) imprisonment, (3) substance abuse, (4) severe mental illness, (5) supported psychiatric housing, (6) psychiatric admission, and (7) chronic medical condition. The outcome was vaccine uptake of two doses against SARS-CoV-2 infection. We calculated cumulative vaccine uptake and adjusted vaccination incidence rate ratios (IRRs) relative to the general population by sex and population group. Findings: The cohort included 4,935,344 individuals, of whom 4,277,380 (86·7%) received two doses of vaccine. Lower cumulative vaccine uptake was found for all socially deprived and psychiatrically vulnerable population groups compared with the general population. Lowest uptake was found for people below 65 years experiencing homelessness (54·6%, 95% confidence interval (CI) 53·4-55·8, p<0·0001). After adjustment for age and calendar time, homelessness was associated with markedly lower rates of vaccine uptake (IRR 0·5, 95% CI 0·5-0·6 in males and 0·4, 0·4-0·5 in females) with similar results for imprisonment. Lower vaccine uptake was also found for most of the psychiatric groups with the lower IRR for substance abuse (IRR 0·7, 0·7–0·7 in males and 0·8, 0·8-0·8 in females). Individuals with new-onset severe mental illness and, especially, those in supported psychiatric housing and with chronic medical conditions had the highest vaccine uptake among the studied population groups. Interpretation: Especially, socially deprived population groups, but also individuals with psychiatric vulnerability need higher priority in the implementation of the vaccination strategy to increase equity in immunization uptake. Funding: Novo Nordisk Foundation.

UR - http://www.scopus.com/inward/record.url?scp=85126981518&partnerID=8YFLogxK

U2 - 10.1016/j.lanepe.2022.100355

DO - 10.1016/j.lanepe.2022.100355

M3 - Journal article

C2 - 35350631

AN - SCOPUS:85126981518

VL - 16

JO - The Lancet Regional Health - Europe

JF - The Lancet Regional Health - Europe

SN - 2666-7762

M1 - 100355

ER -