Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

Thea Emily Benson*, Anne Gaml-Sørensen, Andreas Ernst, Nis Brix, Karin Sørig Hougaard, Katia Keglberg Hærvig, Jens Peter Ellekilde Bonde, Sandra Søgaard Tøttenborg, Christian H Lindh, Cecilia Høst Ramlau-Hansen, Gunnar Toft*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

Original languageEnglish
Article number1742
JournalInternational Journal of Environmental Research and Public Health
Pages (from-to)1-12
Number of pages12
Publication statusPublished - Feb 2021


  • bisphenol
  • endocrine disruptor
  • epidemiology
  • male fertility
  • semen quality


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