Department of Economics and Business Economics

Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study

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Urinary bisphenol A and pubertal development in Chinese school-aged girls : a cross-sectional study. / Miao, Maohua; Wang, Ziliang; Liu, Xiaoqin et al.

In: Environmental Health: A Global Access Science Source, Vol. 16, No. 1, 27.07.2017, p. 80.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Miao, M, Wang, Z, Liu, X, Liang, H, Zhou, Z, Tan, H, Yuan, W & Li, D-K 2017, 'Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study', Environmental Health: A Global Access Science Source, vol. 16, no. 1, pp. 80. https://doi.org/10.1186/s12940-017-0290-9

APA

Miao, M., Wang, Z., Liu, X., Liang, H., Zhou, Z., Tan, H., Yuan, W., & Li, D-K. (2017). Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study. Environmental Health: A Global Access Science Source, 16(1), 80. https://doi.org/10.1186/s12940-017-0290-9

CBE

Miao M, Wang Z, Liu X, Liang H, Zhou Z, Tan H, Yuan W, Li D-K. 2017. Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study. Environmental Health: A Global Access Science Source. 16(1):80. https://doi.org/10.1186/s12940-017-0290-9

MLA

Vancouver

Miao M, Wang Z, Liu X, Liang H, Zhou Z, Tan H et al. Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study. Environmental Health: A Global Access Science Source. 2017 Jul 27;16(1):80. https://doi.org/10.1186/s12940-017-0290-9

Author

Miao, Maohua ; Wang, Ziliang ; Liu, Xiaoqin et al. / Urinary bisphenol A and pubertal development in Chinese school-aged girls : a cross-sectional study. In: Environmental Health: A Global Access Science Source. 2017 ; Vol. 16, No. 1. pp. 80.

Bibtex

@article{df85a229eb6e4308a331eff35a89ab10,
title = "Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study",
abstract = "BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited.METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9-18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs).RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9-12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development.CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group.",
keywords = "Journal Article",
author = "Maohua Miao and Ziliang Wang and Xiaoqin Liu and Hong Liang and Zhijun Zhou and Hui Tan and Wei Yuan and De-Kun Li",
year = "2017",
month = jul,
day = "27",
doi = "10.1186/s12940-017-0290-9",
language = "English",
volume = "16",
pages = "80",
journal = "Environmental Health: A Global Access Science Source",
issn = "1476-069X",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Urinary bisphenol A and pubertal development in Chinese school-aged girls

T2 - a cross-sectional study

AU - Miao, Maohua

AU - Wang, Ziliang

AU - Liu, Xiaoqin

AU - Liang, Hong

AU - Zhou, Zhijun

AU - Tan, Hui

AU - Yuan, Wei

AU - Li, De-Kun

PY - 2017/7/27

Y1 - 2017/7/27

N2 - BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited.METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9-18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs).RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9-12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development.CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group.

AB - BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited.METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9-18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs).RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9-12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development.CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group.

KW - Journal Article

U2 - 10.1186/s12940-017-0290-9

DO - 10.1186/s12940-017-0290-9

M3 - Journal article

C2 - 28750633

VL - 16

SP - 80

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

SN - 1476-069X

IS - 1

ER -