Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers

Øyvind Omland; David Sherson; Åse Marie Hansen; Torben Sigsgaard; Herman Autrup; E Overgaard

Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers

Øyvind Omland, David Sherson, Åse Marie Hansen, Torben Sigsgaard, Herman Autrup, E Overgaard

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

5 Citations (Scopus)

Abstract

Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.

Original language	English
Journal	Cancer Detection and Prevention
Volume	20
Issue	1
Pages (from-to)	57-62
Number of pages	6
ISSN	0361-090X
Publication status	Published - 1996

Keywords

Adult
Aged
Air Pollutants, Occupational
Biological Markers
Chromatography, High Pressure Liquid
Humans
Industry
Male
Middle Aged
Mutagens
Occupational Exposure
Polycyclic Hydrocarbons, Aromatic
Pyrenes

Cite this

@article{e76f4f45e1f041d5992f1fdb4d4170ba,

title = "Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers",

abstract = "Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.",

keywords = "Adult, Aged, Air Pollutants, Occupational, Biological Markers, Chromatography, High Pressure Liquid, Humans, Industry, Male, Middle Aged, Mutagens, Occupational Exposure, Polycyclic Hydrocarbons, Aromatic, Pyrenes",

author = "{\O}yvind Omland and David Sherson and Hansen, {{\AA}se Marie} and Torben Sigsgaard and Herman Autrup and E Overgaard",

year = "1996",

language = "English",

volume = "20",

pages = "57--62",

journal = "Cancer Detection and Prevention",

issn = "0361-090X",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers

AU - Omland, Øyvind

AU - Sherson, David

AU - Hansen, Åse Marie

AU - Sigsgaard, Torben

AU - Autrup, Herman

AU - Overgaard, E

PY - 1996

Y1 - 1996

N2 - Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.

AB - Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) mu g/m3. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p <0.001, r2 = 0.69. Only foundry work (p <0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.

KW - Adult

KW - Aged

KW - Air Pollutants, Occupational

KW - Biological Markers

KW - Chromatography, High Pressure Liquid

KW - Humans

KW - Industry

KW - Male

KW - Middle Aged

KW - Mutagens

KW - Occupational Exposure

KW - Polycyclic Hydrocarbons, Aromatic

KW - Pyrenes

M3 - Journal article

C2 - 8907204

SN - 0361-090X

VL - 20

SP - 57

EP - 62

JO - Cancer Detection and Prevention

JF - Cancer Detection and Prevention

IS - 1

ER -

Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers

Abstract

Keywords

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