Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • Chunxue Bai, Fudan University, Shanghai Respiratory Research Institution
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  • Sanjay H. Chotirmall, Nanyang Technological University
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  • Jordi Rello, Vall d’Hebron Research Institute, CIBER - Center for Biomedical Research Network, CHU Nîmes
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  • George A. Alba, Harvard University
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  • Leo C. Ginns, Harvard University
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  • Jerry A. Krishnan, University of Illinois at Chicago
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  • Robert Rogers, Harvard University
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  • Elisabeth Bendstrup
  • Pierre Regis Burgel, Universite Paris 5
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  • James D. Chalmers, University of Dundee
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  • Abigail Chua, Stony Brook University
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  • Kristina A. Crothers, University of Washington, Seattle
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  • Abhijit Duggal, Cleveland Clinic Foundation
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  • Yeon Wook Kim, Seoul National University
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  • John G. Laffey, National University of Ireland
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  • Carlos M. Luna, Universidad de Buenos Aires
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  • Michael S. Niederman, Cornell University
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  • Ganesh Raghu, University of Washington
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  • Julio A. Ramirez, University of Louisville
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  • Jordi Riera, Vall d’Hebron Research Institute, CIBER - Center for Biomedical Research Network, Autonomous University of Barcelona, CIBERESUCICOVID
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  • Oriol Roca, Vall d’Hebron Research Institute, CIBER - Center for Biomedical Research Network, Autonomous University of Barcelona
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  • Maximiliano Tamae-Kakazu, Michigan State University
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  • Antoni Torres, CIBER - Center for Biomedical Research Network, University of Barcelona, CIBERESUCICOVID
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  • Richard R. Watkins, Northeastern Ohio Universities College of Medicine, Cleveland Clinic Akron General
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  • Miriam Barrecheguren, Autonomous University of Barcelona, CIBER - Center for Biomedical Research Network
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  • Mirko Belliato, IRCCS Fondazione Policlinico San Matteo - Pavia
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  • Hassan A. Chami, American University of Beirut
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  • Rongchang Chen, Southern University of Science and Technology
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  • Gustavo A. Cortes-Puentes, Mayo Clinic Rochester, MN
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  • Charles Delacruz, Yale University
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  • Margaret M. Hayes, Beth Israel Deaconess Medical Center
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  • Leo M.A. Heunks, University of Amsterdam
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  • Steven R. Holets, Mayo Clinic Rochester, MN
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  • Catherine L. Hough, Oregon Health and Science University
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  • Sugeet Jagpal, Robert Wood Johnson University Hospital
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  • Kyeongman Jeon, Sungkyunkwan University
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  • Takeshi Johkoh, Kansai Rosai Hospital
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  • May M. Lee, University of Southern California
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  • Janice Liebler, University of Southern California
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  • Gerry N. McElvaney, Beaumont Hospital, Dublin
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  • Ari Moskowitz, Beth Israel Deaconess Medical Center
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  • Richard A. Oeckler, Mayo Clinic Rochester, MN
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  • Iñigo Ojanguren, Autonomous University of Barcelona, CIBER - Center for Biomedical Research Network
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  • Anthony O’regan, National University of Ireland
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  • Mathias W. Pletz, Friedrich Schiller University Jena
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  • Chin Kook Rhee, Catholic University of Korea
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  • Marcus J. Schultz, University of Amsterdam
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  • Enrico Storti, Ospedale Maggiore
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  • Charlie Strange, Medical University of South Carolina
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  • Carey C. Thomson, Mount Auburn Hospital, Harvard University
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  • Francesca J. Torriani, University of California at San Diego
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  • Xun Wang, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University
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  • Wim Wuyts, KU Leuven
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  • Tao Xu, Qingdao University
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  • Dawei Yang, Fudan University, Shanghai Respiratory Research Institution
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  • Ziqiang Zhang, Tongji Hospital Tongji University
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  • Kevin C. Wilson, Boston University

Background: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby improving outcomes and facilitating future research. Methods: An International Task Force was composed and agreement regarding courses of action was measured using the Convergence of Opinion on Recommendations and Evidence (CORE) process. 70% agreement was necessary to make a consensus suggestion. Results: The Task Force made consensus suggestions to treat patients with acute COVID-19 pneumonia with remdesivir and dexamethasone but suggested against hydroxychloroquine except in the context of a clinical trial; these are revisions of prior suggestions resulting from the interim publication of several randomised trials. It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. The Task Force was unable to reach sufficient agreement to yield consensus suggestions for the post-hospital care of COVID-19 survivors. The Task Force fell one vote shy of suggesting routine screening for depression, anxiety and post-traumatic stress disorder. Conclusions: The Task Force addressed questions related to pharmacotherapy in patients with COVID-19 and the post-hospital care of survivors, yielding several consensus suggestions. Management options for which there is insufficient agreement to formulate a suggestion represent research priorities.

Original languageEnglish
Article number200287
JournalEuropean Respiratory Review
Volume29
Issue157
Number of pages15
ISSN0905-9180
DOIs
Publication statusPublished - Sep 2020

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