Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1

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Standard

Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1. / Akhtar, Hashaam; Hamming, Ole Jensen; Jan, Syed Umer; Akhtar, Samar; Terczynska-Dyla, Ewa; Siupka, Piotr; Shafique, Adeena; Hartmann, Rune; Sadia, Hajra.

In: Pakistan journal of pharmaceutical sciences, Vol. 29, No. 3, 01.05.2016, p. 795-799.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Akhtar, H, Hamming, OJ, Jan, SU, Akhtar, S, Terczynska-Dyla, E, Siupka, P, Shafique, A, Hartmann, R & Sadia, H 2016, 'Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1', Pakistan journal of pharmaceutical sciences, vol. 29, no. 3, pp. 795-799.

APA

Akhtar, H., Hamming, O. J., Jan, S. U., Akhtar, S., Terczynska-Dyla, E., Siupka, P., ... Sadia, H. (2016). Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1. Pakistan journal of pharmaceutical sciences, 29(3), 795-799.

CBE

Akhtar H, Hamming OJ, Jan SU, Akhtar S, Terczynska-Dyla E, Siupka P, Shafique A, Hartmann R, Sadia H. 2016. Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1. Pakistan journal of pharmaceutical sciences. 29(3):795-799.

MLA

Akhtar, Hashaam et al. "Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1". Pakistan journal of pharmaceutical sciences. 2016, 29(3). 795-799.

Vancouver

Akhtar H, Hamming OJ, Jan SU, Akhtar S, Terczynska-Dyla E, Siupka P et al. Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1. Pakistan journal of pharmaceutical sciences. 2016 May 1;29(3):795-799.

Author

Akhtar, Hashaam ; Hamming, Ole Jensen ; Jan, Syed Umer ; Akhtar, Samar ; Terczynska-Dyla, Ewa ; Siupka, Piotr ; Shafique, Adeena ; Hartmann, Rune ; Sadia, Hajra. / Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1. In: Pakistan journal of pharmaceutical sciences. 2016 ; Vol. 29, No. 3. pp. 795-799.

Bibtex

@article{a60861fffb324546a2ce7378a1639add,
title = "Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1",
abstract = "The functional receptor for type III interferons (IFNs) is a heterodimer of IFNLR1 and IL10R2. IFNLR1 is expressed in a highly tissue specific manner, with epithelial and liver tissue as the prime expressing tissues in humans. However, knowledge about the molecular pathways responsible for regulating the expression of IFNLR1 is yet unknown. In this study, various bioinformatics tools were used to predict the scores of signal peptides of IFNλR1 and IFNαR1, which was considered as an important difference in the expression of both receptors or participation in regulating the IFNLR1 gene. In silico study revealed that the signal peptide of IFNαR1 had more potential than the signal peptide of IFNλR1 but changing the signal peptide of wild type IFNλR1 with the signal peptide of IFNαR1 in wet lab had barely shown any differences. Selective expression of IFNλR1 was considered to be a plus point towards the targeted anti-viral activity of IFNλs but artificial control on its expression will surely make IFNλs a better drug with enhanced activity. The results of this study may help us in contributing some understanding towards the mechanisms involved in the selective expression of IFNLR1 and exceptionalities involved.",
keywords = "Expression, IFNLR1, Interferon lambda, Signal peptide, Transcription factor binding sites (TBS)",
author = "Hashaam Akhtar and Hamming, {Ole Jensen} and Jan, {Syed Umer} and Samar Akhtar and Ewa Terczynska-Dyla and Piotr Siupka and Adeena Shafique and Rune Hartmann and Hajra Sadia",
year = "2016",
month = "5",
day = "1",
language = "English",
volume = "29",
pages = "795--799",
journal = "Pakistan journal of pharmaceutical sciences",
issn = "1011-601X",
publisher = "Pakistan Journal of Pharmaceutical Sciences",
number = "3",

}

RIS

TY - JOUR

T1 - Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1

AU - Akhtar, Hashaam

AU - Hamming, Ole Jensen

AU - Jan, Syed Umer

AU - Akhtar, Samar

AU - Terczynska-Dyla, Ewa

AU - Siupka, Piotr

AU - Shafique, Adeena

AU - Hartmann, Rune

AU - Sadia, Hajra

PY - 2016/5/1

Y1 - 2016/5/1

N2 - The functional receptor for type III interferons (IFNs) is a heterodimer of IFNLR1 and IL10R2. IFNLR1 is expressed in a highly tissue specific manner, with epithelial and liver tissue as the prime expressing tissues in humans. However, knowledge about the molecular pathways responsible for regulating the expression of IFNLR1 is yet unknown. In this study, various bioinformatics tools were used to predict the scores of signal peptides of IFNλR1 and IFNαR1, which was considered as an important difference in the expression of both receptors or participation in regulating the IFNLR1 gene. In silico study revealed that the signal peptide of IFNαR1 had more potential than the signal peptide of IFNλR1 but changing the signal peptide of wild type IFNλR1 with the signal peptide of IFNαR1 in wet lab had barely shown any differences. Selective expression of IFNλR1 was considered to be a plus point towards the targeted anti-viral activity of IFNλs but artificial control on its expression will surely make IFNλs a better drug with enhanced activity. The results of this study may help us in contributing some understanding towards the mechanisms involved in the selective expression of IFNLR1 and exceptionalities involved.

AB - The functional receptor for type III interferons (IFNs) is a heterodimer of IFNLR1 and IL10R2. IFNLR1 is expressed in a highly tissue specific manner, with epithelial and liver tissue as the prime expressing tissues in humans. However, knowledge about the molecular pathways responsible for regulating the expression of IFNLR1 is yet unknown. In this study, various bioinformatics tools were used to predict the scores of signal peptides of IFNλR1 and IFNαR1, which was considered as an important difference in the expression of both receptors or participation in regulating the IFNLR1 gene. In silico study revealed that the signal peptide of IFNαR1 had more potential than the signal peptide of IFNλR1 but changing the signal peptide of wild type IFNλR1 with the signal peptide of IFNαR1 in wet lab had barely shown any differences. Selective expression of IFNλR1 was considered to be a plus point towards the targeted anti-viral activity of IFNλs but artificial control on its expression will surely make IFNλs a better drug with enhanced activity. The results of this study may help us in contributing some understanding towards the mechanisms involved in the selective expression of IFNLR1 and exceptionalities involved.

KW - Expression

KW - IFNLR1

KW - Interferon lambda

KW - Signal peptide

KW - Transcription factor binding sites (TBS)

UR - http://www.scopus.com/inward/record.url?scp=84979666781&partnerID=8YFLogxK

M3 - Journal article

VL - 29

SP - 795

EP - 799

JO - Pakistan journal of pharmaceutical sciences

JF - Pakistan journal of pharmaceutical sciences

SN - 1011-601X

IS - 3

ER -