Unraveling recombination rate evolution using ancestral recombination maps

TY - JOUR

T1 - Unraveling recombination rate evolution using ancestral recombination maps

AU - Munch, Kasper

AU - Schierup, Mikkel H

AU - Mailund, Thomas

N1 - © 2014 The Authors. Bioessays published by WILEY Periodicals, Inc.

PY - 2014/7/14

Y1 - 2014/7/14

N2 - Recombination maps of ancestral species can be constructed from comparative analyses of genomes from closely related species, exemplified by a recently published map of the human-chimpanzee ancestor. Such maps resolve differences in recombination rate between species into changes along individual branches in the speciation tree, and allow identification of associated changes in the genomic sequences. We describe how coalescent hidden Markov models are able to call individual recombination events in ancestral species through inference of incomplete lineage sorting along a genomic alignment. In the great apes, speciation events are sufficiently close in time that a map can be inferred for the ancestral species at each internal branch - allowing evolution of recombination rate to be tracked over evolutionary time scales from speciation event to speciation event. We see this approach as a way of characterizing the evolution of recombination rate and the genomic properties that influence it.

AB - Recombination maps of ancestral species can be constructed from comparative analyses of genomes from closely related species, exemplified by a recently published map of the human-chimpanzee ancestor. Such maps resolve differences in recombination rate between species into changes along individual branches in the speciation tree, and allow identification of associated changes in the genomic sequences. We describe how coalescent hidden Markov models are able to call individual recombination events in ancestral species through inference of incomplete lineage sorting along a genomic alignment. In the great apes, speciation events are sufficiently close in time that a map can be inferred for the ancestral species at each internal branch - allowing evolution of recombination rate to be tracked over evolutionary time scales from speciation event to speciation event. We see this approach as a way of characterizing the evolution of recombination rate and the genomic properties that influence it.

U2 - 10.1002/bies.201400047

DO - 10.1002/bies.201400047

M3 - Journal article

C2 - 25043668

SN - 0265-9247

VL - 36

SP - 892

EP - 900

JO - BioEssays

JF - BioEssays

IS - 9

ER -