TY - JOUR
T1 - Understanding brain states across spacetime informed by whole-brain modelling
AU - Vohryzek, Jakub
AU - Cabral, Joana
AU - Vuust, Peter
AU - Deco, Gustavo
AU - Kringelbach, Morten L.
PY - 2022
Y1 - 2022
N2 - In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent functioning, supported by sufficient intrinsic instability needed for optimal adaptability. The emergent, spontaneous balance between order and disorder in brain activity over spacetime underpins distinct brain states. For example, depression is characterized by excessively rigid, highly ordered states, while psychedelics can bring about more disordered, sometimes overly flexible states. Recent developments in systems, computational and theoretical neuroscience have started to make inroads into the characterization of such complex dynamics over space and time. Here,we 2022 The Author(s) Published by the Royal Society. All rights reserved.
AB - In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent functioning, supported by sufficient intrinsic instability needed for optimal adaptability. The emergent, spontaneous balance between order and disorder in brain activity over spacetime underpins distinct brain states. For example, depression is characterized by excessively rigid, highly ordered states, while psychedelics can bring about more disordered, sometimes overly flexible states. Recent developments in systems, computational and theoretical neuroscience have started to make inroads into the characterization of such complex dynamics over space and time. Here,we 2022 The Author(s) Published by the Royal Society. All rights reserved.
KW - complexity
KW - connectomics
KW - emergence
KW - functional magnetic resonance imaging
KW - spatio-Temporal dynamics
KW - whole-brain models
UR - http://www.scopus.com/inward/record.url?scp=85131126754&partnerID=8YFLogxK
U2 - 10.1098/rsta.2021.0247
DO - 10.1098/rsta.2021.0247
M3 - Review
C2 - 35599554
AN - SCOPUS:85131126754
SN - 1364-503X
VL - 380
JO - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
JF - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
IS - 2227
M1 - 20210247
ER -