Abstract
In recent years DNA microarray and high-throughput sequencing technologies have challenged the “gene-centric” view that pre-mRNA is the only RNA species transcribed off protein-coding genes. Instead unorthodox transcription from within genic- and intergenic regions has been demonstrated to occur at an unexpected level. Adding to the complexity, RNAs that normally escape detection due to their short-lived nature have been identified upon depletion of the cellular machineries that normally facilitate their rapid clearance. In this talk I will describe our efforts to identify unconventional stable and unstable RNAs emitted from within, and immediately upstream human protein-coding genes. Mechanisms of their production and turn-over as well as their possible functions will be discussed
| Original language | English |
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| Publication date | Apr 2011 |
| Number of pages | 1 |
| DOIs | |
| Publication status | Published - Apr 2011 |
| Event | Mosbacher Kolloquium: Mechanisms of RNA-mediated regulation - Baden, Germany Duration: 7 Apr 2011 → 9 Apr 2011 Conference number: 62 |
Conference
| Conference | Mosbacher Kolloquium |
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| Number | 62 |
| Country/Territory | Germany |
| City | Baden |
| Period | 07/04/2011 → 09/04/2011 |