Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Kai Triebner, University of Bergen
  • ,
  • Ersilia Bifulco, University of Bergen
  • ,
  • Jose Barrera-Gómez, Barcelona Institute for Global Health, Pompeu Fabra University, CIBER - Center for Biomedical Research Network
  • ,
  • Xavier Basagaña, Barcelona Institute for Global Health, Pompeu Fabra University, CIBER - Center for Biomedical Research Network
  • ,
  • Bryndís Benediktsdóttir, University of Iceland
  • ,
  • Bertil Forsberg, Umeå University
  • ,
  • Karl A. Franklin, Umeå University
  • ,
  • Vanessa Garcia-Larsen, Johns Hopkins University
  • ,
  • Bénédicte Leynaert, University of Rochester
  • ,
  • Eva Lindberg, Uppsala University
  • ,
  • Jesús Martínez-Moratalla, Albacete University Hospital Complex, University of Castilla-La Mancha
  • ,
  • Nerea Muniozguren-Agirre, Unit of Epidemiology and Public Health
  • ,
  • Isabelle Pin, Universite Grenoble Alpes, French National Institute of Health and Medical Research, Institute for Advanced Biosciences
  • ,
  • Chantal Raherison, Universite de Bordeaux
  • ,
  • Antonio Pereira-Vega, Hospital Universitario Juan Ramón Jiménez
  • ,
  • Vivi Schlünssen
  • Antonia Valentin, Barcelona Institute for Global Health, Pompeu Fabra University, CIBER - Center for Biomedical Research Network
  • ,
  • Steinar Hustad, University of Bergen
  • ,
  • Francisco Gómez Real, University of Bergen
  • ,
  • Payam Dadvand, Barcelona Institute for Global Health, Pompeu Fabra University, CIBER - Center for Biomedical Research Network

Background: Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites are associated with higher or lower concentrations of estrogens and may thus alter the female sex hormone balance. Objective: To study whether exposure to UVR, as a modifiable lifestyle factor, is associated with levels of sex hormones (17β-estradiol, estrone, estrone 3-sulfate, testosterone, dehydroepiandrosterone sulfate), gonadotropins (follicle stimulating hormone, luteinizing hormone) as well as sex hormone binding globulin in postmenopausal women, and thus investigate whether managing UVR exposure can influence the hormone balance, with potential benefits for the biological aging process. Methods: The study included 580 postmenopausal women from six European countries, participating in the European Community Respiratory Health Survey (2010–2014). Average UVR exposure during the month before blood sampling was estimated based on personal sun behavior and ambient levels. Hormone concentrations were measured in serum using state-of-the-art methods. Subsequently we applied linear mixed-effects models, including center as random intercept, hormone concentrations (one at a time) as outcome and UVR, age, skin type, body mass index, vitamin D from dietary sources, smoking, age at completed full-time education and season of blood sampling as fixed-effect predictors. Results: One interquartile range increase in UVR exposure was associated with decreased levels of 17β-estradiol (-15.6 pmol/L, 95 % Confidence Interval (CI): -27.69, -3.51) and estrone (-13.36 pmol/L, 95 % CI: -26.04, -0.68) and increased levels of follicle stimulating hormone (9.34IU/L, 95 % CI: 2.91, 15.77) and luteinizing hormone (13.86 IU/daL, 95 % CI: 2.48, 25.25). Conclusions: Exposure to UVR is associated with decreased estrogens and increased gonadotropins in postmenopausal women, a status associated with osteoporosis, lung function decline and other adverse health effects. This study indicates that managing UVR exposure has potential to influence the hormone balance and counteract adverse health conditions after menopause.

Original languageEnglish
JournalMaturitas
Volume145
Pages (from-to)49-55
Number of pages7
ISSN0378-5122
DOIs
Publication statusPublished - Mar 2021

    Research areas

  • Estrogens, Menopause, Reproductive aging, Sunlight, Vitamin D

See relations at Aarhus University Citationformats

ID: 210337265