Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men

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Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men. / Hostrup, M.; Jessen, S.; Onslev, J.; Clausen, T.; Porsbjerg, C.

In: Scandinavian Journal of Medicine & Science in Sports, Vol. 27, No. 7, 07.2017, p. 684-691.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hostrup, M, Jessen, S, Onslev, J, Clausen, T & Porsbjerg, C 2017, 'Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men', Scandinavian Journal of Medicine & Science in Sports, vol. 27, no. 7, pp. 684-691. https://doi.org/10.1111/sms.12677

APA

Hostrup, M., Jessen, S., Onslev, J., Clausen, T., & Porsbjerg, C. (2017). Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men. Scandinavian Journal of Medicine & Science in Sports, 27(7), 684-691. https://doi.org/10.1111/sms.12677

CBE

Hostrup M, Jessen S, Onslev J, Clausen T, Porsbjerg C. 2017. Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men. Scandinavian Journal of Medicine & Science in Sports. 27(7):684-691. https://doi.org/10.1111/sms.12677

MLA

Vancouver

Hostrup M, Jessen S, Onslev J, Clausen T, Porsbjerg C. Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men. Scandinavian Journal of Medicine & Science in Sports. 2017 Jul;27(7):684-691. https://doi.org/10.1111/sms.12677

Author

Hostrup, M. ; Jessen, S. ; Onslev, J. ; Clausen, T. ; Porsbjerg, C. / Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men. In: Scandinavian Journal of Medicine & Science in Sports. 2017 ; Vol. 27, No. 7. pp. 684-691.

Bibtex

@article{83c45747a9ac4cd4aac06a544a774efb,
title = "Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men",
abstract = "While chronic systemic administration of glucocorticoids increases muscle Na+,K+ ATPase content, such effect is unexplored after therapeutic inhalation. We investigated the effect of therapeutic inhalation of the glucocorticoid budesonide on Na+,K+ ATPase content of skeletal muscle in men. Ten healthy trained subjects, aged 23 +/- 4years (mean +/- 95% CI), participated in the study. Before and after 2weeks of daily inhalation of budesonide (1.6mg/day), a biopsy was taken from the vastus lateralis muscle for measurement of Na+,K+ ATPase content and blood samples were drawn for determination of plasma budesonide, cortisol, and K+. Subjects' performance during cycling to fatigue at 90% of incremental peak power output (iPPO) was measured in response to 4mg inhaled terbutaline to maximally stimulate Na+,K+ ATPase activity. Plasma concentrations of budesonide rose to 5.0 +/- 1.6nM with the intervention, whereas no changes were observed in plasma cortisol. Muscle Na+,K+ ATPase content increased (P0.01) by 46 +/- 34 pmol/(g wet wt) (17% increase) with the intervention. Cycling performance at 90% of iPPO did not change (P=0.21) with the intervention (203 vs 214s) in response to terbutaline. The present observations show that therapeutic inhalation of glucocorticoids increases muscle Na+,K+ ATPase content, but does not enhance high-intensity cycling endurance in response to terbutaline.",
keywords = "Na+, K+ pump, ATPase, glucocorticos-teroids, ICS, ion handling, muscle fatigue, doping, physiology, beta(2)-adrenergic, SKELETAL-MUSCLE, INHALED TERBUTALINE, SUBMAXIMAL EXERCISE, PUMP ACTIVITY, TRAINED MEN, K+, ASTHMA, NA+, GLUCOCORTICOIDS, BETA(2)-AGONISTS",
author = "M. Hostrup and S. Jessen and J. Onslev and T. Clausen and C. Porsbjerg",
year = "2017",
month = jul,
doi = "10.1111/sms.12677",
language = "English",
volume = "27",
pages = "684--691",
journal = "Scandinavian Journal of Medicine & Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "7",

}

RIS

TY - JOUR

T1 - Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men

AU - Hostrup, M.

AU - Jessen, S.

AU - Onslev, J.

AU - Clausen, T.

AU - Porsbjerg, C.

PY - 2017/7

Y1 - 2017/7

N2 - While chronic systemic administration of glucocorticoids increases muscle Na+,K+ ATPase content, such effect is unexplored after therapeutic inhalation. We investigated the effect of therapeutic inhalation of the glucocorticoid budesonide on Na+,K+ ATPase content of skeletal muscle in men. Ten healthy trained subjects, aged 23 +/- 4years (mean +/- 95% CI), participated in the study. Before and after 2weeks of daily inhalation of budesonide (1.6mg/day), a biopsy was taken from the vastus lateralis muscle for measurement of Na+,K+ ATPase content and blood samples were drawn for determination of plasma budesonide, cortisol, and K+. Subjects' performance during cycling to fatigue at 90% of incremental peak power output (iPPO) was measured in response to 4mg inhaled terbutaline to maximally stimulate Na+,K+ ATPase activity. Plasma concentrations of budesonide rose to 5.0 +/- 1.6nM with the intervention, whereas no changes were observed in plasma cortisol. Muscle Na+,K+ ATPase content increased (P0.01) by 46 +/- 34 pmol/(g wet wt) (17% increase) with the intervention. Cycling performance at 90% of iPPO did not change (P=0.21) with the intervention (203 vs 214s) in response to terbutaline. The present observations show that therapeutic inhalation of glucocorticoids increases muscle Na+,K+ ATPase content, but does not enhance high-intensity cycling endurance in response to terbutaline.

AB - While chronic systemic administration of glucocorticoids increases muscle Na+,K+ ATPase content, such effect is unexplored after therapeutic inhalation. We investigated the effect of therapeutic inhalation of the glucocorticoid budesonide on Na+,K+ ATPase content of skeletal muscle in men. Ten healthy trained subjects, aged 23 +/- 4years (mean +/- 95% CI), participated in the study. Before and after 2weeks of daily inhalation of budesonide (1.6mg/day), a biopsy was taken from the vastus lateralis muscle for measurement of Na+,K+ ATPase content and blood samples were drawn for determination of plasma budesonide, cortisol, and K+. Subjects' performance during cycling to fatigue at 90% of incremental peak power output (iPPO) was measured in response to 4mg inhaled terbutaline to maximally stimulate Na+,K+ ATPase activity. Plasma concentrations of budesonide rose to 5.0 +/- 1.6nM with the intervention, whereas no changes were observed in plasma cortisol. Muscle Na+,K+ ATPase content increased (P0.01) by 46 +/- 34 pmol/(g wet wt) (17% increase) with the intervention. Cycling performance at 90% of iPPO did not change (P=0.21) with the intervention (203 vs 214s) in response to terbutaline. The present observations show that therapeutic inhalation of glucocorticoids increases muscle Na+,K+ ATPase content, but does not enhance high-intensity cycling endurance in response to terbutaline.

KW - Na+

KW - K+ pump

KW - ATPase

KW - glucocorticos-teroids

KW - ICS

KW - ion handling

KW - muscle fatigue

KW - doping

KW - physiology

KW - beta(2)-adrenergic

KW - SKELETAL-MUSCLE

KW - INHALED TERBUTALINE

KW - SUBMAXIMAL EXERCISE

KW - PUMP ACTIVITY

KW - TRAINED MEN

KW - K+

KW - ASTHMA

KW - NA+

KW - GLUCOCORTICOIDS

KW - BETA(2)-AGONISTS

U2 - 10.1111/sms.12677

DO - 10.1111/sms.12677

M3 - Journal article

C2 - 27060857

VL - 27

SP - 684

EP - 691

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

SN - 0905-7188

IS - 7

ER -