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Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men

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  • M. Hostrup, IOC Sports Med Copenhagen
  • ,
  • S. Jessen, University of Copenhagen
  • ,
  • J. Onslev, University of Copenhagen
  • ,
  • T. Clausen
  • C. Porsbjerg, University of Copenhagen

While chronic systemic administration of glucocorticoids increases muscle Na+,K+ ATPase content, such effect is unexplored after therapeutic inhalation. We investigated the effect of therapeutic inhalation of the glucocorticoid budesonide on Na+,K+ ATPase content of skeletal muscle in men. Ten healthy trained subjects, aged 23 +/- 4years (mean +/- 95% CI), participated in the study. Before and after 2weeks of daily inhalation of budesonide (1.6mg/day), a biopsy was taken from the vastus lateralis muscle for measurement of Na+,K+ ATPase content and blood samples were drawn for determination of plasma budesonide, cortisol, and K+. Subjects' performance during cycling to fatigue at 90% of incremental peak power output (iPPO) was measured in response to 4mg inhaled terbutaline to maximally stimulate Na+,K+ ATPase activity. Plasma concentrations of budesonide rose to 5.0 +/- 1.6nM with the intervention, whereas no changes were observed in plasma cortisol. Muscle Na+,K+ ATPase content increased (P0.01) by 46 +/- 34 pmol/(g wet wt) (17% increase) with the intervention. Cycling performance at 90% of iPPO did not change (P=0.21) with the intervention (203 vs 214s) in response to terbutaline. The present observations show that therapeutic inhalation of glucocorticoids increases muscle Na+,K+ ATPase content, but does not enhance high-intensity cycling endurance in response to terbutaline.

Original languageEnglish
JournalScandinavian Journal of Medicine & Science in Sports
Pages (from-to)684-691
Number of pages8
Publication statusPublished - Jul 2017

    Research areas

  • Na+, K+ pump, ATPase, glucocorticos-teroids, ICS, ion handling, muscle fatigue, doping, physiology, beta(2)-adrenergic, SKELETAL-MUSCLE, INHALED TERBUTALINE, SUBMAXIMAL EXERCISE, PUMP ACTIVITY, TRAINED MEN, K+, ASTHMA, NA+, GLUCOCORTICOIDS, BETA(2)-AGONISTS

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