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Two-chamber hydrogen generation and application: access to pressurized deuterium gas

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Two-chamber hydrogen generation and application : access to pressurized deuterium gas. / Modvig, Amalie; Andersen, Thomas L; Taaning, Rolf H; Lindhardt, Anders T; Skrydstrup, Troels.

In: Journal of Organic Chemistry, Vol. 79, No. 12, 20.06.2014, p. 5861-8.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Author

Modvig, Amalie ; Andersen, Thomas L ; Taaning, Rolf H ; Lindhardt, Anders T ; Skrydstrup, Troels. / Two-chamber hydrogen generation and application : access to pressurized deuterium gas. In: Journal of Organic Chemistry. 2014 ; Vol. 79, No. 12. pp. 5861-8.

Bibtex

@article{74d77826152b49f7afe8450c11ea905e,
title = "Two-chamber hydrogen generation and application: access to pressurized deuterium gas",
abstract = "Hydrogen and deuterium gas were produced and directly applied in a two-chamber system. These gaseous reagents were generated by the simple reaction of metallic zinc with HCl in water for H2 and DCl in deuterated water for D2. The setup proved efficient in classical Pd-catalyzed reductions of ketones, alkynes, alkenes, etc. in near-quantitative yields. The method was extended to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline derivatives. Finally, CX-546 and Olaparib underwent efficient Ir-catalyzed hydrogen isotope exchange reactions.",
keywords = "Alkenes, Alkynes, Catalysis, Deuterium, Dioxanes, Hydrogen, Isotope Labeling, Kinetics, Metals, Oxidation-Reduction, Phthalazines, Piperazines, Piperidines, Quinolines",
author = "Amalie Modvig and Andersen, {Thomas L} and Taaning, {Rolf H} and Lindhardt, {Anders T} and Troels Skrydstrup",
year = "2014",
month = jun,
day = "20",
doi = "10.1021/jo500801t",
language = "English",
volume = "79",
pages = "5861--8",
journal = "The Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "AMER CHEMICAL SOC",
number = "12",

}

RIS

TY - JOUR

T1 - Two-chamber hydrogen generation and application

T2 - access to pressurized deuterium gas

AU - Modvig, Amalie

AU - Andersen, Thomas L

AU - Taaning, Rolf H

AU - Lindhardt, Anders T

AU - Skrydstrup, Troels

PY - 2014/6/20

Y1 - 2014/6/20

N2 - Hydrogen and deuterium gas were produced and directly applied in a two-chamber system. These gaseous reagents were generated by the simple reaction of metallic zinc with HCl in water for H2 and DCl in deuterated water for D2. The setup proved efficient in classical Pd-catalyzed reductions of ketones, alkynes, alkenes, etc. in near-quantitative yields. The method was extended to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline derivatives. Finally, CX-546 and Olaparib underwent efficient Ir-catalyzed hydrogen isotope exchange reactions.

AB - Hydrogen and deuterium gas were produced and directly applied in a two-chamber system. These gaseous reagents were generated by the simple reaction of metallic zinc with HCl in water for H2 and DCl in deuterated water for D2. The setup proved efficient in classical Pd-catalyzed reductions of ketones, alkynes, alkenes, etc. in near-quantitative yields. The method was extended to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline derivatives. Finally, CX-546 and Olaparib underwent efficient Ir-catalyzed hydrogen isotope exchange reactions.

KW - Alkenes

KW - Alkynes

KW - Catalysis

KW - Deuterium

KW - Dioxanes

KW - Hydrogen

KW - Isotope Labeling

KW - Kinetics

KW - Metals

KW - Oxidation-Reduction

KW - Phthalazines

KW - Piperazines

KW - Piperidines

KW - Quinolines

U2 - 10.1021/jo500801t

DO - 10.1021/jo500801t

M3 - Journal article

C2 - 24870212

VL - 79

SP - 5861

EP - 5868

JO - The Journal of Organic Chemistry

JF - The Journal of Organic Chemistry

SN - 0022-3263

IS - 12

ER -