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Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

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  • Bjørn A Nexø
  • Sara B Jensen, Department of Biomedicine, Aarhus University, The Bartholin Building, Wilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark; Laboratory for Epigenetics and Environment, Centre National de Génotypage, CEA - Institut de Génomique, 2 rue Gaston Crémieux, 91000 Evry, France.
  • ,
  • Kari K Nissen
  • Bettina Hansen
  • Magdalena J Laska, Aarhus University

BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).

RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.

CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.

Original languageEnglish
Article number57
JournalBMC Neurology
Pages (from-to)57
Publication statusPublished - 30 Apr 2016
Externally publishedYes

    Research areas

  • Diabetes Mellitus, Type 1/genetics, Endogenous Retroviruses/genetics, Humans, Multiple Sclerosis/genetics

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