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Twenty-year mortality of adult patients with primary immune thrombocytopenia: a Danish population-based cohort study

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Twenty-year mortality of adult patients with primary immune thrombocytopenia : a Danish population-based cohort study. / Frederiksen, Henrik; dybdal, Merete Lund; Nørgaard, Mette.

In: British Journal of Haematology, Vol. 166, No. 2, 07.2014, p. 260-7.

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@article{6aacddda3c2841ce855f6aabe7bd6b56,
title = "Twenty-year mortality of adult patients with primary immune thrombocytopenia: a Danish population-based cohort study",
abstract = "Studies have reported a 1·3- to 2·2-fold higher mortality rate among patients with primary immune thrombocytopenia (ITP) compared to the general population. However, long-term mortality estimates as well as cause-specific mortality data are sparse. In our population-based cohort of adult patients with newly diagnosed ITP and up to 37 years of follow-up, the 5-year, 10-year and 20-year mortality among the ITP patients was 22{\%}, 34{\%} and 49{\%}, respectively. The mortality in the ITP cohort was consistently higher than in the in the general population cohort yielding an adjusted hazard ratio (HR) of 1·5 [95{\%} confidence interval (CI): 1·2-1·8]. The adjusted HRs of mortality due to cardiovascular disease, infection, bleeding and haematological cancer were 1·5 (95{\%} CI: 1·1-1·5), 2·4 (95{\%} CI: 1·0-5·7), 6·2 (95{\%} CI: 2·8-13·5) and 5·7 (95{\%} CI: 2·1-15·7), respectively, whereas mortality due to solid cancer and other causes were similar in ITP patients and the general population. We conclude that mortality rates among ITP patients are higher than in the general population, predominantly as a result of increased cardiovascular disease, infection, bleeding and haematological cancer cause-specific mortalities.",
keywords = "Adolescent, Adult, Age Distribution, Cardiovascular Diseases, Cause of Death, Cohort Studies, Comorbidity, Denmark, Female, Hematologic Neoplasms, Hemorrhage, Humans, Male, Middle Aged, Opportunistic Infections, Purpura, Thrombocytopenic, Idiopathic, Sex Distribution, Young Adult",
author = "Henrik Frederiksen and dybdal, {Merete Lund} and Mette N{\o}rgaard",
note = "{\circledC} 2014 John Wiley & Sons Ltd.",
year = "2014",
month = "7",
doi = "10.1111/bjh.12869",
language = "English",
volume = "166",
pages = "260--7",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Twenty-year mortality of adult patients with primary immune thrombocytopenia

T2 - a Danish population-based cohort study

AU - Frederiksen, Henrik

AU - dybdal, Merete Lund

AU - Nørgaard, Mette

N1 - © 2014 John Wiley & Sons Ltd.

PY - 2014/7

Y1 - 2014/7

N2 - Studies have reported a 1·3- to 2·2-fold higher mortality rate among patients with primary immune thrombocytopenia (ITP) compared to the general population. However, long-term mortality estimates as well as cause-specific mortality data are sparse. In our population-based cohort of adult patients with newly diagnosed ITP and up to 37 years of follow-up, the 5-year, 10-year and 20-year mortality among the ITP patients was 22%, 34% and 49%, respectively. The mortality in the ITP cohort was consistently higher than in the in the general population cohort yielding an adjusted hazard ratio (HR) of 1·5 [95% confidence interval (CI): 1·2-1·8]. The adjusted HRs of mortality due to cardiovascular disease, infection, bleeding and haematological cancer were 1·5 (95% CI: 1·1-1·5), 2·4 (95% CI: 1·0-5·7), 6·2 (95% CI: 2·8-13·5) and 5·7 (95% CI: 2·1-15·7), respectively, whereas mortality due to solid cancer and other causes were similar in ITP patients and the general population. We conclude that mortality rates among ITP patients are higher than in the general population, predominantly as a result of increased cardiovascular disease, infection, bleeding and haematological cancer cause-specific mortalities.

AB - Studies have reported a 1·3- to 2·2-fold higher mortality rate among patients with primary immune thrombocytopenia (ITP) compared to the general population. However, long-term mortality estimates as well as cause-specific mortality data are sparse. In our population-based cohort of adult patients with newly diagnosed ITP and up to 37 years of follow-up, the 5-year, 10-year and 20-year mortality among the ITP patients was 22%, 34% and 49%, respectively. The mortality in the ITP cohort was consistently higher than in the in the general population cohort yielding an adjusted hazard ratio (HR) of 1·5 [95% confidence interval (CI): 1·2-1·8]. The adjusted HRs of mortality due to cardiovascular disease, infection, bleeding and haematological cancer were 1·5 (95% CI: 1·1-1·5), 2·4 (95% CI: 1·0-5·7), 6·2 (95% CI: 2·8-13·5) and 5·7 (95% CI: 2·1-15·7), respectively, whereas mortality due to solid cancer and other causes were similar in ITP patients and the general population. We conclude that mortality rates among ITP patients are higher than in the general population, predominantly as a result of increased cardiovascular disease, infection, bleeding and haematological cancer cause-specific mortalities.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Cardiovascular Diseases

KW - Cause of Death

KW - Cohort Studies

KW - Comorbidity

KW - Denmark

KW - Female

KW - Hematologic Neoplasms

KW - Hemorrhage

KW - Humans

KW - Male

KW - Middle Aged

KW - Opportunistic Infections

KW - Purpura, Thrombocytopenic, Idiopathic

KW - Sex Distribution

KW - Young Adult

U2 - 10.1111/bjh.12869

DO - 10.1111/bjh.12869

M3 - Journal article

C2 - 24690142

VL - 166

SP - 260

EP - 267

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -