Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

Gilles Vanwalleghem*, Yannick Morias, Alain Beschin, David E. Szymkowski, Etienne Pays

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

4 Citations (Scopus)

Abstract

Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growth, but also to contribute to tissue damage, shortening the survival time of infected mice. Using a dominant-negative version of TNF to discriminate between the effects of the membrane-form versus the soluble form of TNF, we show that the second form is involved in neither parasite control nor induction of liver injury. Therefore, soluble TNF is likely not a major contributor to disease outcome. We propose that membrane-bound TNF is responsible for both T. brucei control and host pathology.

Original languageEnglish
Article number6165
JournalScientific Reports
Volume7
Issue1
ISSN2045-2322
DOIs
Publication statusPublished - 1 Dec 2017
Externally publishedYes

Fingerprint

Dive into the research topics of 'Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine'. Together they form a unique fingerprint.

Cite this