Trileaflet Semilunar Valve Reconstruction: Pulsatile In Vitro Evaluation

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

OBJECTIVE: Residual regurgitation is common after congenital surgery for right ventricular outflow tract malformation. It is accepted as there is no competent valve solution in a growing child. We investigated a new surgical technique of trileaflet semilunar valve reconstruction possessing the potential of remaining sufficient and allow for some growth with the child. In this proof-of-concept study, our aim was to evaluate if it is achievable as a functional pulmonary valve reconstruction in vitro.

METHODS: Explanted pulmonary trunks from porcine hearts were evaluated in a pulsatile flow-loop model. First, the native pulmonary trunk was investigated, after which the native leaflets were explanted. Then, trileaflet semilunar valve reconstruction was performed and investigated. All valves were initially investigated at a flow output of 4 L/min and subsequently at 7 L/min. The characterization was based on hydrodynamic pressure and echocardiographic measurements.

RESULTS: Eight pulmonary trunks were evaluated. All valves are competent on colour Doppler. There is no difference in mean pulmonary systolic artery pressure gradient at 4 L/min (P = 0.32) and at 7 L/min (P = 0.20). Coaptation length is increased in the neo-valve at 4 L/min (P < 0.001, P < 0.001, P = 0.008) and at 7 L/min (P < 0.001, P = 0.006, P = 0.006). A windmill shape is observed in all neo-valves.

CONCLUSIONS: Trileaflet semilunar valve reconstruction is sufficient and not-stenotic. It resulted in an increased coaptation length and a windmill shape, which is speculated to decrease with growth of the patient, yet remain sufficient as a transitional procedure until a long-term solution is feasible. Further in vivo investigations are warranted.

Original languageEnglish
Article numberivac227
JournalInteractive Cardiovascular and Thoracic Surgery
Volume35
Issue4
Number of pages9
ISSN1569-9293
DOIs
Publication statusPublished - Sep 2022

Bibliographical note

© The Author(s) 2022. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery.

    Research areas

  • CHILDREN, Congenital, In vitro, Neo-valve, Pulmonary valve reconstruction, TSVR

See relations at Aarhus University Citationformats

ID: 281000444