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Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity

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Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by microorganisms. Here we show that the two natural products triculamin and alboverticillin, originally isolated in 1967 and 1958, respectively, with potent and specific activity against mycobacteria are in fact the same lasso peptide. We solved the structure using 2D NMR spectroscopy and expanded on the previously reported bioactivity. Through genome sequencing, we identify the responsible biosynthetic gene clusters, which curiously revealed that, unlike any known lasso peptides, their precursor peptides appear to have a follower instead of a leader peptide.

Original languageEnglish
JournalJournal of Natural Products
Pages (from-to)1514-1521
Number of pages8
Publication statusPublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society and American Society of Pharmacognosy.

    Research areas

  • ANANTIN, ANTAGONIST, MATURATION, NATRIURETIC-FACTOR ANF, SEQUENCE, TUBERCULOSIS, Multigene Family, Peptides/chemistry, Biological Products, Protein Processing, Post-Translational

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