Transport unplugged:: KCCs are regulated through an N-terminal plug of the ion pathway

Rasmus Kock Flygaard; Caroline Neumann; Joseph Anthony Lyons; Poul Nissen

doi:10.15252/embj.2021108371

Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway

Rasmus Kock Flygaard, Caroline Neumann, Joseph Anthony Lyons, Poul Nissen^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

2 Citations (Scopus)

Abstract

The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

Original language	English
Article number	e108371
Journal	EMBO Journal
Volume	40
Issue	14
Number of pages	3
ISSN	0261-4189
DOIs	https://doi.org/10.15252/embj.2021108371
Publication status	Published - Jul 2021

Keywords

Binding Sites
Chlorides/metabolism
Humans
Phosphorylation
Protein Domains
Symporters/genetics

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10.15252/embj.2021108371

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title = "Transport unplugged:: KCCs are regulated through an N-terminal plug of the ion pathway",

abstract = "The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.",

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author = "{Kock Flygaard}, Rasmus and Caroline Neumann and {Anthony Lyons}, Joseph and Poul Nissen",

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Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway. / Kock Flygaard, Rasmus; Neumann, Caroline; Anthony Lyons, Joseph et al.
In: EMBO Journal, Vol. 40, No. 14, e108371, 07.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review

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T2 - KCCs are regulated through an N-terminal plug of the ion pathway

AU - Kock Flygaard, Rasmus

AU - Neumann, Caroline

AU - Anthony Lyons, Joseph

AU - Nissen, Poul

PY - 2021/7

Y1 - 2021/7

N2 - The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

AB - The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

KW - Binding Sites

KW - Chlorides/metabolism

KW - Humans

KW - Phosphorylation

KW - Protein Domains

KW - Symporters/genetics

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M3 - Comment/debate/letter to the editor

C2 - 34031898

AN - SCOPUS:85106217134

SN - 0261-4189

VL - 40

JO - EMBO Journal

JF - EMBO Journal

IS - 14

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ER -

Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway

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Keywords

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