Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway

Rasmus Kock Flygaard, Caroline Neumann, Joseph Anthony Lyons, Poul Nissen*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review


The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

Original languageEnglish
Article numbere108371
JournalEMBO Journal
Number of pages3
Publication statusPublished - Jul 2021


  • Binding Sites
  • Chlorides/metabolism
  • Humans
  • Phosphorylation
  • Protein Domains
  • Symporters/genetics


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