Transport of ions across the choroid plexus epithelium

Research output: Contribution to book/anthology/report/proceedingBook chapterEducationpeer-review

Abstract

The choroid plexus is a small but very active epithelial structure located in the brain ventricles. Here, it secretes the majority of the cerebrospinal fluid that covers the brain and spinal cord. The epithelial cells of the choroid plexus have a high rate of fluid secretion and differs from many other secretory epithelia in the organization of the main ion transporters. One striking difference is the apical localization of the Na,K ATPase. In recent years focus has increased on the role of the ion transporters as more studies have indicated implication of increased transport in disorders such as hydrocephalus, idiopathic intracranial hypertension and sequelae following intraventricular hemorrhages. The role of the choroid plexus ion transporters in regulation of composition of the cerebrospinal fluid has also been the focus in research in recent years as a regulator of breathing, blood pressure and heart rate.

This chapter focuses on the role of key ion transporters involved in cerebrospinal fluid secretion and cerebrospinal fluid ion composition. The chapter gives an overview of established factors as well as controversies in the area of ion transporters and finally discusses the future perspectives related to targeting treatment of cerebrospinal fluid disorders toward transporters on the choroid plexus epithelium.

Original languageEnglish
Title of host publicationCerebrospinal fluid and subarachnoid space : Clinical Anatomy and Physiology: Volume 1
EditorsR. Shane Tubbs
Number of pages15
Volume1
Place of publicationLondon
PublisherAcademic Press
Publication dateOct 2022
Pages257-271
Chapter18
ISBN (Print)9780128195093
ISBN (Electronic)9780128195109
Publication statusPublished - Oct 2022

Keywords

  • Cerebrospinal fluid composition
  • Cerebrospinal fluid pH
  • Cerebrospinal fluid secretion
  • Choroid plexus epithelium
  • Iontransporters

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