Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder. / Greve, Aja Neergaard; Jepsen, Jens Richardt Møllegaard; Mortensen, Erik Lykke et al.
In: Schizophrenia Research, Vol. 246, 08.2022, p. 195-201.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder
AU - Greve, Aja Neergaard
AU - Jepsen, Jens Richardt Møllegaard
AU - Mortensen, Erik Lykke
AU - Uher, Rudolf
AU - Mackenzie, Lynn
AU - Foldager, Leslie
AU - Gantriis, Ditte
AU - Burton, Birgitte Klee
AU - Ellersgaard, Ditte
AU - Christiani, Camilla Jerlang
AU - Spang, Katrine S.
AU - Hemager, Nicoline
AU - Uddin, Jamal
AU - Henriksen, Maria Toft
AU - Zahle, Kate Kold
AU - Stadsgaard, Henriette
AU - Plessen, Kerstin J.
AU - Thorup, Anne A.E.
AU - Nordentoft, Merete
AU - Mors, Ole
AU - Bliksted, Vibeke
N1 - Funding Information: This work was supported by the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) (grant number R248-2017-2003 , R155-2014-1724 , R102-A9118 ), Aarhus University , Aarhus University Hospital Psychiatry, the Mental Health Services of the Capital Region of Denmark and the Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen . The sources of funding had no involvement in the study design, data collection, data analysis, interpretation, writing of the manuscript or decision to submit the manuscript for publication. Publisher Copyright: © 2022 The Authors
PY - 2022/8
Y1 - 2022/8
N2 - Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year-old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.
AB - Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year-old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.
KW - Familial high risk
KW - Heritability
KW - Neurocognition
KW - Transgenerational transmission
UR - http://www.scopus.com/inward/record.url?scp=85133420621&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2022.06.032
DO - 10.1016/j.schres.2022.06.032
M3 - Journal article
C2 - 35802954
AN - SCOPUS:85133420621
VL - 246
SP - 195
EP - 201
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -