Translational implications of bradyarrhythmia in hibernating brown bears

Lisa A. Gottlieb; Alina L. Evans; Boris Fuchs; Ole Fröbert; Anna Björkenheim

doi:10.14814/phy2.15550

Translational implications of bradyarrhythmia in hibernating brown bears

Lisa A. Gottlieb^*, Alina L. Evans, Boris Fuchs, Ole Fröbert, Anna Björkenheim

^*Corresponding author for this work

Department of Clinical Medicine - SDCA-Steno Diabetes Center Aarhus

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.

Original language	English
Article number	e15550
Journal	Physiological Reports
Volume	11
Issue	1
ISSN	2051-817X
DOIs	https://doi.org/10.14814/phy2.15550
Publication status	Published - Jan 2023

Keywords

bradyarrhythmia
brown bear
hibernation
sinus arrest
sinus node disease
sinus pause
syncope
translational model
Ursus arctos

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10.14814/phy2.15550Licence: CC BY

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title = "Translational implications of bradyarrhythmia in hibernating brown bears",

abstract = "The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.",

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AU - Fuchs, Boris

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AU - Björkenheim, Anna

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N2 - The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.

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KW - sinus arrest

KW - sinus node disease

KW - sinus pause

KW - syncope

KW - translational model

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Translational implications of bradyarrhythmia in hibernating brown bears

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