Translational control in brain pathologies: biological significance and therapeutic opportunities

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Translational control in brain pathologies : biological significance and therapeutic opportunities. / Delaidelli, Alberto; Jan, Asad; Herms, Jochen; Sorensen, Poul H.

In: Acta Neuropathologica, Vol. 137, No. 4, 04.2019, p. 535-555.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

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Delaidelli, A, Jan, A, Herms, J & Sorensen, PH 2019, 'Translational control in brain pathologies: biological significance and therapeutic opportunities', Acta Neuropathologica, vol. 137, no. 4, pp. 535-555. https://doi.org/10.1007/s00401-019-01971-8

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Delaidelli, Alberto ; Jan, Asad ; Herms, Jochen ; Sorensen, Poul H. / Translational control in brain pathologies : biological significance and therapeutic opportunities. In: Acta Neuropathologica. 2019 ; Vol. 137, No. 4. pp. 535-555.

Bibtex

@article{a9ca7151a92f4a1e9218dc6aabbc4438,
title = "Translational control in brain pathologies: biological significance and therapeutic opportunities",
abstract = "Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a crucial regulatory checkpoint for this process. Translational control allows specific cell types to respond to rapid changes in the microenvironment or to serve specific functions. For example, neurons use mRNA transport to achieve local protein synthesis at significant distances from the nucleus, the site of RNA transcription. Altered expression or functions of the various components of the translational machinery have been linked to several pathologies in the central nervous system. In this review, we provide a brief overview of the basic principles of mRNA translation, and discuss alterations of this process relevant to CNS disease conditions, with a focus on brain tumors and chronic neurological conditions. Finally, synthesizing this knowledge, we discuss the opportunities to exploit the biology of altered mRNA translation for novel therapies in brain disorders, as well as how studying these alterations can shed new light on disease mechanisms.",
keywords = "Brain tumors, eEF2 kinase, mRNA translation, Neurodegenerative diseases, RNA-binding proteins, Translation control",
author = "Alberto Delaidelli and Asad Jan and Jochen Herms and Sorensen, {Poul H.}",
year = "2019",
month = "4",
doi = "10.1007/s00401-019-01971-8",
language = "English",
volume = "137",
pages = "535--555",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Translational control in brain pathologies

T2 - biological significance and therapeutic opportunities

AU - Delaidelli, Alberto

AU - Jan, Asad

AU - Herms, Jochen

AU - Sorensen, Poul H.

PY - 2019/4

Y1 - 2019/4

N2 - Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a crucial regulatory checkpoint for this process. Translational control allows specific cell types to respond to rapid changes in the microenvironment or to serve specific functions. For example, neurons use mRNA transport to achieve local protein synthesis at significant distances from the nucleus, the site of RNA transcription. Altered expression or functions of the various components of the translational machinery have been linked to several pathologies in the central nervous system. In this review, we provide a brief overview of the basic principles of mRNA translation, and discuss alterations of this process relevant to CNS disease conditions, with a focus on brain tumors and chronic neurological conditions. Finally, synthesizing this knowledge, we discuss the opportunities to exploit the biology of altered mRNA translation for novel therapies in brain disorders, as well as how studying these alterations can shed new light on disease mechanisms.

AB - Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a crucial regulatory checkpoint for this process. Translational control allows specific cell types to respond to rapid changes in the microenvironment or to serve specific functions. For example, neurons use mRNA transport to achieve local protein synthesis at significant distances from the nucleus, the site of RNA transcription. Altered expression or functions of the various components of the translational machinery have been linked to several pathologies in the central nervous system. In this review, we provide a brief overview of the basic principles of mRNA translation, and discuss alterations of this process relevant to CNS disease conditions, with a focus on brain tumors and chronic neurological conditions. Finally, synthesizing this knowledge, we discuss the opportunities to exploit the biology of altered mRNA translation for novel therapies in brain disorders, as well as how studying these alterations can shed new light on disease mechanisms.

KW - Brain tumors

KW - eEF2 kinase

KW - mRNA translation

KW - Neurodegenerative diseases

KW - RNA-binding proteins

KW - Translation control

UR - http://www.scopus.com/inward/record.url?scp=85061331373&partnerID=8YFLogxK

U2 - 10.1007/s00401-019-01971-8

DO - 10.1007/s00401-019-01971-8

M3 - Review

VL - 137

SP - 535

EP - 555

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 4

ER -